Olopatadine hydrochloride, H1 receptor antagonist (ab143195)

Overview

  • Product name

    Olopatadine hydrochloride, H1 receptor antagonist
  • Description

    Selective H1 receptor antagonist
  • Biological description

    Selective H1 receptor antagonist (Ki = 31.6 nm; IC50 = 559 µM). Inhibits the release of histamine, tryptase and prostaglandin D2 in a concentration-dependent manner. Active in vivo.
  • CAS Number

    140462-76-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    2-[(11Z)-11-[3-(Dimethylamino)propylidene]-6H-benzo[c][1]benzoxepin-2-yl]acetic acid hydrochloride
  • Molecular weight

    373.87
  • Molecular formula

    C21H24ClNO3
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water to 75 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CN(C)CCC=C1C2=CC=CC=C2COC3=C1C=C(C=C3)CC(=O)O.Cl
  • Source

    Synthetic

References

This product has been referenced in:

  • Higashi M  et al. Histamine H1-receptor antagonistic drug olopatadine suppresses TSLP in atopic dermatitis model mice. Allergol Int 62:137-8 (2013). Read more (PubMed: 23172358) »
  • Sharif NA  et al. Characterization of the ocular antiallergic and antihistaminic effects of olopatadine (AL-4943A), a novel drug for treating ocular allergic diseases. J Pharmacol Exp Ther 278:1252-61 (1996). Read more (PubMed: 8819509) »

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