Overview

  • Product name

    Oltipraz, Nrf2 activator
  • Description

    Nrf2 activator
  • Biological description

    Nrf2 activator. Increases ARE (anti-oxidant response element)-driven gene expression. Increases expression of phase-II enzymes. Shows anti-cancer properties. Active in vivo.
  • Purity

    > 98%
  • CAS Number

    64224-21-1
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-Methyl-5-pyrazin-2-yldithiole-3-thione
  • Molecular weight

    226.34
  • Molecular formula

    C8H6N2S3
  • PubChem identifier

    47318
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=C(SSC1=S)C2=NC=CN=C2
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Konwinski RR  et al. Oltipraz, 3H-1,2-dithiole-3-thione, and sulforaphane induce overlapping and protective antioxidant responses in murine microglial cells. Toxicol Lett 153:343-55 (2004). Read more (PubMed: 15454310) »
  • Ramos-Gomez M  et al. Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice. Proc Natl Acad Sci U S A 98:3410-5 (2001). Read more (PubMed: 11248092) »
  • Kwak MK  et al. Role of phase 2 enzyme induction in chemoprotection by dithiolethiones. Mutat Res 480-481:305-15 (2001). Read more (PubMed: 11506823) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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