Overview

  • Product name

    OM173-alphaA, DNMT3B and FTase inhibitor
  • Description

    DNMT3B and FTase inhibitor. Antibiotic and antimycoplasmal agent.
  • Biological description

    Potent, selective DNA (cytosine-5)-methyltransferase 3B (DNMT3B) inhibitor (IC50 = 500nM). Farnesyltransferase (FTase) inhibitor (IC50 = 3.2μM). Antibiotic and antimycoplasmal agent. Nanaomycin A methyl ester.
  • Purity

    > 95%
  • CAS Number

    58286-56-9
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Kuck D  et al. Nanaomycin A selectively inhibits DNMT3B and reactivates silenced tumor suppressor genes in human cancer cells. Mol Cancer Ther 9:3015-23 (2010). Read more (PubMed: 20833755) »
  • Iwasaki S & Omura S Search for protein farnesyltransferase inhibitors of microbial origin: our strategy and results as well as the results obtained by other groups. J Antibiot (Tokyo) 60:1-12 (2007). Read more (PubMed: 17390583) »
  • Iwai Y  et al. OM-173, new nanaomycin-type antibiotics produced by a strain of Streptomyces. Taxonomy, production, isolation and biological properties. J Antibiot (Tokyo) 36:1268-74 (1983). Read more (PubMed: 6643276) »

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