omega-Agatoxin IVA, Ca2+ channel blocker (P and Q type) (ab120210)

Overview

  • Product name
    omega-Agatoxin IVA, Ca2+ channel blocker (P and Q type)
  • Description
    Ca2+ channel blocker (P and Q type)
  • Biological description
    Synthetic peptide, originally isolated from Agelenopsis aperta spider venom. Selective blocker of Cav2.1 (P/Q type) channels.
  • CAS Number
    145017-83-0
  • Chemical structure
    Chemical Structure

Properties

Images

  • Many VGCC subtypes contribute to calcium signalling in ganglion cell bodies.

    Summary of Ca2+ imaging results in RGC somata showing the following changes in paired pulse Ca2+ signal in response to drugs (applied during the second K+ pulse) compared to their control paired K+ pulses (K): 10 µM nifedipine (29%±7%; p = 0.0003; n = 20), 100 µM verapamil (VPM; 39%±5%; p<0.0001; n = 17), 400 nM ω-agatoxin IVA (AGT; 35%±14%; p = 0.0364; n = 9), 3 µM ω-conotoxin-GVIA (CTX; 23%±10%; p = 0.0423; n = 15), 3 µM mibefradil (MIB; 21%±6%; p = 0.0011; n = 16) and 200 nM TTX (40%±9%; p = 0.0004; n = 14).

    (From Figure 7C of Sargoy et al).

References

This product has been referenced in:
See all 6 Publications for this product

Customer reviews and Q&As

Question
Answer

Our peptides structure is governed primarily by the disulphide bridges in the molecule. These disulphide bridges are in the correct place for ω-Agatoxin IVA and the amino acid sequence is correct.

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