omega-Conotoxin GVIA, Ca2+ channel blocker (N type) (ab120215)
Key features and details
- Ca2+ channel blocker (N type)
- CAS Number: 106375-28-4
- Soluble in water
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
omega-Conotoxin GVIA, Ca2+ channel blocker (N type) -
Description
Ca2+ channel blocker (N type) -
Biological description
Synthetic toxin originally isolated from Conus geographus. Specific blocker of Cav2.2 (N-type) Ca2+ channels. Binds to the Cav2.2α1 subunit (α1B) and its action is only partially reversible.
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General notes
Item is subject to Export Control Regulations and Licensing requirements. Please contact Customer Service for more information and lead times.
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CAS Number
106375-28-4 -
Chemical structure
Properties
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Molecular weight
3037.40 -
Molecular formula
C120H182N38O43S6 -
Sequence
CKSXGSSCSXTSYNCCRSCNXYTKRCY (Modifications: C-terminal amide; X-4 = Hyp; X-10 = Hyp; X-21 = Hyp; Disulfide bonds: 1-16, 8-19, 15-26) -
PubChem identifier
16133838 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
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Research areas
Images
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Chemical Structure - omega-Conotoxin GVIA, Ca2+ channel blocker (N type) (ab120215)2D chemical structure image of ab120215, omega-Conotoxin GVIA, Ca2+ channel blocker (N type)
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
References (9)
ab120215 has been referenced in 9 publications.
- Blazon M et al. N-type calcium channels control GABAergic transmission in brain areas related to fear and anxiety. OBM Neurobiol 5:N/A (2021). PubMed: 33521586
- Toft-Bertelsen TL et al. Regulation of Ca2+ channels by SNAP-25 via recruitment of syntaxin-1 from plasma membrane clusters. Mol Biol Cell 27:3329-3341 (2016). PubMed: 27605709
- Prigge CL et al. M1 ipRGCs Influence Visual Function through Retrograde Signaling in the Retina. J Neurosci 36:7184-97 (2016). PubMed: 27383593
- Rose SJ et al. The first knockin mouse model of episodic ataxia type 2. Exp Neurol 261C:553-562 (2014). PubMed: 25109669
- Bock R et al. Strengthening the accumbal indirect pathway promotes resilience to compulsive cocaine use. Nat Neurosci 16:632-8 (2013). PubMed: 23542690
- Vilar B et al. Alleviating pain hypersensitivity through activation of type 4 metabotropic glutamate receptor. J Neurosci 33:18951-65 (2013). PubMed: 24285900
- Jurkovicová-Tarabová B et al. Repertoire of high voltage-activated Ca2+ channels in the lateral superior olive: functional analysis in wild-type, Ca(v)1.3(-/-), and Ca(v)1.2DHP(-/-) mice. J Neurophysiol 108:365-79 (2012). PubMed: 22539826
- Faria LC et al. Interneuronal calcium channel abnormalities in posttraumatic epileptogenic neocortex. Neurobiol Dis 45:821-8 (2012). PubMed: 22172650
- Farrell SR et al. Modulation of voltage-gated ion channels in rat retinal ganglion cells mediated by somatostatin receptor subtype 4. J Neurophysiol 104:1347-54 (2010). PubMed: 20573967