omega-Conotoxin GVIA, Ca2+ channel blocker (N type) (ab120215)
- Datasheet
- References (8)
Overview
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Product name
omega-Conotoxin GVIA, Ca2+ channel blocker (N type) -
Description
Ca2+ channel blocker (N type) -
Biological description
Synthetic toxin originally isolated from Conus geographus. Specific blocker of Cav2.2 (N-type) Ca2+ channels. Binds to the Cav2.2α1 subunit (α1B) and its action is only partially reversible. -
Purity
> 96% -
General notes
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CAS Number
106375-28-4 -
Chemical structure
Properties
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Molecular weight
3037.40 -
Molecular formula
C120H182N38O43S6 -
Sequence
CKSXGSSCSXTSYNCCRSCNXYTKRCY (Modifications: C-terminal amide; X-4 = Hyp; X-10 = Hyp; X-21 = Hyp; Disulfide bonds: 1-16, 8-19, 15-26) -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in water -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one week. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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Source
Synthetic
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Research areas
References
This product has been referenced in:
- Terlau H & Olivera BM Conus venoms: a rich source of novel ion channel-targeted peptides. Physiol Rev 84:41-68 (2004). Read more (PubMed: 14715910) »
- Feng ZP et al. Residue Gly1326 of the N-type calcium channel alpha 1B subunit controls reversibility of omega-conotoxin GVIA and MVIIA block. J Biol Chem 276:15728-35 (2001). Read more (PubMed: 11279062) »
- Olivera BM et al. Calcium channel diversity and neurotransmitter release: the omega-conotoxins and omega-agatoxins. Annu Rev Biochem 63:823-67 (1994). Read more (PubMed: 7979255) »
