Omeprazole, H+/K+ ATPase proton pump inhibitor (ab142993)

Overview

  • Product name

    Omeprazole, H+/K+ ATPase proton pump inhibitor
  • Description

    Selective, irreversible H+/K+ ATPase proton pump inhibitor
  • Biological description

    Selective, irreversible H+/K+ ATPase proton pump inhibitor (IC50 = 5.2 µM). Inhibits gastric acid secretion. Inhibits cytochrome P450 mediated drug metabolism. Active in vitro and in vivo. Cell and blood brain barrier permeable.
  • Purity

    > 95%
  • CAS Number

    73590-58-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    6-Methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]-1H-benzimidazole
  • Molecular weight

    345.42
  • Molecular formula

    C17H19N3O3S
  • PubChem identifier

    4594
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in 1eq. HCl to 50 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=CN=C(C(=C1OC)C)CS(=O)C2=NC3=C(N2)C=C(C=C3)OC
  • Source

    Synthetic

References

This product has been referenced in:

  • Humphries TJ Clinical implications of drug interactions with the cytochrome P-450 enzyme system associated with omeprazole. Dig Dis Sci 36:1665-9 (1991). Read more (PubMed: 1748033) »
  • Lampkin TA  et al. Omeprazole: a novel antisecretory agent for the treatment of acid-peptic disorders. DICP 24:393-402 (1990). Read more (PubMed: 2183494) »
  • Keeling DJ  et al. Studies on the mechanism of action of omeprazole. Biochem Pharmacol 34:2967-73 (1985). Read more (PubMed: 2992525) »

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