Overview

  • Product name

    ONO 1078 (Pranlukast), CysLT1 antagonist
  • Description

    Potent, selective, competitive CysLT1 antagonist
  • Alternative names

    • Pranlukast
  • Biological description

    Potent, selective, competitive CysLT1 antagonist (IC50 values are 7 and 3620 nM for CysLT1 and CysLT2 respectively). Shows bronchodilatory and antiasthmatic effects in vivo.
  • Purity

    > 99%
  • CAS Number

    103177-37-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-[4-Oxo-2-(2H-tetrazol-5-yl)chromen-8-yl]-4-(4-phenylbutoxy)benzamide
  • Molecular weight

    481.50
  • Molecular formula

    C27H23N5O4
  • PubChem identifier

    4887
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC=C(C=C1)CCCCOC2=CC=C(C=C2)C(=O)NC3=CC=CC4=C3OC(=CC4=O)C5=NNN=N5
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Suzuki M  et al. Inhibition of human eosinophil activation by a cysteinyl leukotriene receptor antagonist (pranlukast; ONO-1078). J Asthma 40:395-404 (2003). Read more (PubMed: 12870835) »
  • Nakano R  et al. A leukotriene receptor antagonist, ONO-1078, modulates drug sensitivity and leukotriene C4 efflux in lung cancer cells expressing multidrug resistance protein. Biochem Biophys Res Commun 251:307-12 (1998). Read more (PubMed: 9790952) »
  • Obata T  et al. In vitro antagonism of ONO-1078, a newly developed anti-asthma agent, against peptide leukotrienes in isolated guinea pig tissues. Jpn J Pharmacol 60:227-37 (1992). Read more (PubMed: 1491512) »

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