Anti-ORC1 antibody [7F6/1] - ChIP Grade (ab60)
Key features and details
- Mouse monoclonal [7F6/1] to ORC1 - ChIP Grade
- Reacts with: Human
- Isotype: IgG1
Overview
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Product name
Anti-ORC1 antibody [7F6/1] - ChIP Grade
See all ORC1 primary antibodies -
Description
Mouse monoclonal [7F6/1] to ORC1 - ChIP Grade -
Host species
Mouse -
Species reactivity
Reacts with: Human -
Immunogen
Recombinant full length protein (Human)
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Positive control
- HeLa cells.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Concentration information loading...
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Purity
Protein A purified -
Clonality
Monoclonal -
Clone number
7F6/1 -
Myeloma
Sp2/0-Ag14 -
Isotype
IgG1 -
Light chain type
unknown -
Research areas
Associated products
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ChIP Related Products
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Compatible Secondaries
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Isotype control
Target
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Function
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. -
Sequence similarities
Belongs to the ORC1 family.
Contains 1 BAH domain. -
Developmental stage
Expression is cell-cycle regulated, it starts to accumulate in mid-G1 phase, reaches a peak at the G1/S boundary, and decreases to a basal level in S phase (at protein level). -
Cellular localization
Nucleus. - Information by UniProt
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Database links
- Entrez Gene: 4998 Human
- Omim: 601902 Human
- SwissProt: Q13415 Human
- Unigene: 17908 Human
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Alternative names
- HSORC1 antibody
- MmORC1 antibody
- orc1 antibody
see all
Datasheets and documents
References (3)
ab60 has been referenced in 3 publications.
- Lu F et al. Regulation of DNA replication and chromosomal polyploidy by the MLL-WDR5-RBBP5 methyltransferases. Biol Open 5:1449-1460 (2016). PubMed: 27744293
- Beck DB et al. The role of PR-Set7 in replication licensing depends on Suv4-20h. Genes Dev 26:2580-9 (2012). WB, ChIP ; Human . PubMed: 23152447
- Salsi V et al. HOXD13 binds DNA replication origins to promote origin licensing and is inhibited by geminin. Mol Cell Biol 29:5775-88 (2009). ChIP ; Human, Mouse . PubMed: 19703996