• Product name

  • Description

    Mouse polyclonal to ORC6L
  • Host species

  • Tested applications

    Suitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Full length Human ORC6L protein (AAH63565).

  • Positive control

    • Human pancreas tissue lysate. Cell lysate from transfected 293T cells. Human placenta. HeLa cells.


  • Form

  • Storage instructions

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer

    Preservative: None
    Constituents: PBS, pH 7.2
  • Concentration information loading...
  • Purity

    Protein A purified
  • Clonality

  • Isotype

  • Research areas


Our Abpromise guarantee covers the use of ab88686 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Detects a band of approximately 28 kDa (predicted molecular weight: 28 kDa).
IHC-P Use a concentration of 3 µg/ml. Antigen retrieval is not essential but may optimise staining.
ICC/IF Use a concentration of 10 µg/ml.


  • Function

    Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
  • Involvement in disease

    Defects in ORC6 are the cause of Meier-Gorlin syndrome type 3 (MGORS3) [MIM:613803]. MGORS3 is a syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal.
  • Sequence similarities

    Belongs to the ORC6 family.
  • Post-translational

    Phosphorylated upon DNA damage, probably by ATM or ATR.
  • Cellular localization

  • Information by UniProt
  • Database links

  • Alternative names

    • ORC 6 antibody
    • Orc6 antibody
    • ORC6_HUMAN antibody
    • ORC6L antibody
    • Origin recognition complex subunit 6 antibody
    • origin recognition complex subunit 6 homolog like antibody
    • origin recognition complex subunit 6 homolog like (yeast) antibody
    • origin recognition complex subunit 6 like (yeast) antibody
    see all


  • Anti-ORC6L antibody (ab88686) at 1 µg/ml + Human pancreas tissue lysate at 50 µg

    Predicted band size: 28 kDa
    Observed band size: 28 kDa

  • All lanes : Anti-ORC6L antibody (ab88686) at 1 µg/ml

    Lane 1 : cell lysate from ORC6L transfected 293T cells
    Lane 2 : cell lysate from non transfected 293T cells

    Lysates/proteins at 25 µg per lane.

    Predicted band size: 28 kDa
    Observed band size: 28 kDa

  • ab88686 at 3 µg/ml detecting ORC6L in formalin-fixed paraffin-embedded Human placenta by immunohistochemistry.
  • ab88686 at 10 µg/ml detecting ORC6L in paraformaldehyde fixed, permeabilised HeLa cells by immunofluorescence.


This product has been referenced in:

See 1 Publication for this product

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