Key features and details
- Sheep polyclonal to Orexin A
- Suitable for: IHC-FoFr
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Orexin A antibody
See all Orexin A primary antibodies
DescriptionSheep polyclonal to Orexin A
SpecificityThis antibody is specific for Orexin A.
Tested applicationsSuitable for: IHC-FoFrmore details
Species reactivityReacts with: Human
Predicted to work with: Rat
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We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 7.20
Preservative: 0.1% Sodium azide
Concentration information loading...
Purification notesAmmonium Sulfate fractionation.
Our Abpromise guarantee covers the use of ab35337 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-FoFr||Use at an assay dependent concentration.|
RelevanceOrexin A (hypocretin 1) a 33 amino acid peptide and orexin B (hypocretin 2), a 28 amino acid peptide, are both derived from a common 130 amino acid precursor, prepro orexin. Orexin A and Orexin B stimulate food consumption when administered intracerebroventricularly to rats. Orexin gene expression in the brain is highly restricted to distinct populations of neurons located in specific hypothalamic regions, including the lateral hypothalamic area (LHA), a region implicated in feeding behaviour. Orexin A and orexin B bind to and activate two closely related G protein coupled receptors (GPCRs), termed Orexin 1 (OX1) and Orexin 2 (OX2) receptors. Dysfunction of the orexin peptide system has been linked to narcolepsy.
Cellular localizationRough endoplasmic reticulum. Cytoplasmic vesicle. Cell junction, synapse. Note: Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses.
- HCRT antibody
- HCRT1 antibody
- HCRT2 antibody
ab35337 has been referenced in 1 publication.
- Silva JP et al. Regulation of adaptive behaviour during fasting by hypothalamic Foxa2. Nature 462:646-50 (2009). IHC-FoFr ; Mouse . PubMed: 19956259