Overview

  • Product name

    Oridonin, anti-tumor agent
  • Description

    Antitumor agent. Cell-permeable.
  • Biological description

    Antitumor agent (IC50 = 7.4 μM). Shows apoptotic, antiangiogenic and antiproliferative activity in vitro. Inhibits NF-κB activity and downregualtes BCL-xL. Active in vivo. Cell-permeable.
  • Purity

    > 97%
  • CAS Number

    28957-04-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (1S,4aR,5S,6S,14S)-1,5,6,14-Tetrahydroxy-4,4-dimethyl-8-methylenedecahydro-1H-6,11b-(epoxymethano)-6a,9-methanocyclohepta[a]naphthalen-7(8H)-one
  • Molecular weight

    364.43
  • Molecular formula

    C20H28N5O6
  • PubChem identifier

    457846
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1(CCC(C23C1C(C(C45C2CCC(C4O)C(=C)C5=O)(OC3)O)O)O)C
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Gao FH  et al. Oridonin induces apoptosis and senescence in colorectal cancer cells by increasing histone hyperacetylation and regulation of p16, p21, p27 and c-myc. BMC Cancer 10:610 (2010). Read more (PubMed: 21054888) »
  • Ren KK  et al. The effects of oridonin on cell growth, cell cycle, cell migration and differentiation in melanoma cells. J Ethnopharmacol 103:176-80 (2006). Read more (PubMed: 16169170) »
  • Ikezoe T  et al. Oridonin, a diterpenoid purified from Rabdosia rubescens, inhibits the proliferation of cells from lymphoid malignancies in association with blockade of the NF-kappa B signal pathways. Mol Cancer Ther 4:578-86 (2005). Read more (PubMed: 15827331) »
  • Meade-Tollin LC  et al. Ponicidin and oridonin are responsible for the antiangiogenic activity of Rabdosia rubescens, a constituent of the herbal supplement PC SPES. J Nat Prod 67:2-4 (2004). Read more (PubMed: 14738375) »

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