Overview

  • Product name

  • Description

    Rabbit polyclonal to ORP8
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, ICC/IFmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rhesus monkey
  • Positive control

    • ICC/IF: HeLa cells. WB: U-87 MG whole cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab228990 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/5000 - 1/20000.
ICC/IF 1/100 - 1/1000.

Target

  • Relevance

    ORP8 is a member of the oxysterol-binding protein related protein family. In humans, the gene family consists of 12 members, and extensive splice variation increases the number of encoded protein products substantially. The ORPs have been implicated as sterol sensors that regulate a number of cellular functions including sterol and neutral lipid metabolism, intracellular lipid transport, membrane trafficking and cell signaling. ORP8 has been recently shown to act as a sterol sensor that affects the reverse cholesterol transport process via modulation of ABCA1 expression and macrophage cholesterol efflux.
  • Cellular localization

    Endoplasmic reticulum
  • Database links

  • Alternative names

    • DKFZp686A11164 antibody
    • KIAA1451 antibody
    • MGC126578 antibody
    • MGC133203 antibody
    • MST120 antibody
    • MSTP120 antibody
    • ORP 8 antibody
    • OSBP related protein 8 antibody
    • OSBP10 antibody
    • OSBPL8 antibody
    • Oxysterol binding protein like 8 antibody
    • Oxysterol binding protein like protein 8 antibody
    • Oxysterol binding protein related protein 8 antibody
    see all

Images

  • Anti-ORP8 antibody (ab228990) at 1/10000 dilution + U-87 MG (human glioblastoma-astrocytoma epithelial cell line) whole cell lysate at 30 µg

    Developed using the ECL technique.


    7.5% SDS-PAGE

  • Methanol-fixed HeLa (human epithelial cell line from cervix adenocarcinoma) cells stained for ORP8 (green) using ab228990 (1/500 dilution) in ICC/IF.

    Counterstain: Hoechst 33342 (blue).

References

ab228990 has not yet been referenced specifically in any publications.

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