Orphenadrine citrate (Norflex), mAChR antagonist (ab143275)

Overview

  • Product name

    Orphenadrine citrate (Norflex), mAChR antagonist
  • Description

    mAChR antagonist. Uncompetitive NMDA receptor antagonist.
  • Biological description

    mAChR antagonist (IC50 = 0.37 µM). Uncompetitive NMDA receptor antagonist (IC50 = 16.2 µM). Anti-inflammatory and antinociceptive. Active in vitro and in vivo. Blood-brain barrier permeable.
  • Purity

    > 95%
  • CAS Number

    4682-36-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N,N-Dimethyl-2-[(2-methylphenyl)-phenylmethoxy]ethanamine citrate
  • Molecular weight

    461.50
  • Molecular formula

    C18H23NO.C6H8O7
  • PubChem identifier

    83823
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1(C(OCCN(C)C)C2=CC=CC=C2C)(=CC=CC=C1).OC(CC(CC(O)=O)(C(=O)O)O)=O
  • Source

    Synthetic

References

This product has been referenced in:

  • Rizzatti-Barbosa CM  et al. Therapeutic response of benzodiazepine, orphenadrine citrate and occlusal splint association in TMD pain. Cranio 21:116-20 (2003). Read more (PubMed: 12723857) »
  • Hunskaar S  et al. Antinociceptive effects of orphenadrine citrate in mice. Eur J Pharmacol 111:221-6 (1985). Read more (PubMed: 4018126) »
  • Brocks DR Anticholinergic drugs used in Parkinson's disease: An overlooked class of drugs from a pharmacokinetic perspective. J Pharm Pharm Sci 2:39-46 (0). Read more (PubMed: 10952768) »

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab143275.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up