Key features and details
- Rabbit polyclonal to Orthoreovirus fusion protein p10
- Suitable for: ELISA
- Isotype: IgG
Product nameAnti-Orthoreovirus fusion protein p10 antibody
DescriptionRabbit polyclonal to Orthoreovirus fusion protein p10
Tested applicationsSuitable for: ELISAmore details
Species reactivityReacts with: Other species
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
Concentration information loading...
PurityImmunogen affinity purified
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab26816 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
RelevanceThe p10 fusion-associated small transmembrane protein of avian reovirus induces extensive syncytium formation in transfected cells. The p10-induced cell-cell fusion is restricted by rapid degradation of the majority of newly synthesized p10. The small ectodomain of p10 targets the protein for degradation following p10 insertion into an early membrane compartment. Paradoxically, conservative amino acid substitutions in the p10 ectodomain hydrophobic patch that eliminate fusion activity also increase p10 stability. The small amount of p10 that escapes intracellular degradation accumulates at the cell surface in a relatively stable form, where it mediates cell-cell fusion as a late-stage event in the virus replication cycle. The unusual relationship between a nonstructural viral membrane fusion protein and the replication cycle of a nonenveloped virus has apparently contributed to the evolution of a novel mechanism for restricting the extent of virus-induced cell-cell fusion.
- SwissProt: O12285 Other species
- 10 kDa protein antibody
- Fusion protein p10 antibody
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab26816 has not yet been referenced specifically in any publications.