Overview

  • Product name
    Anti-OSBP1 antibody
    See all OSBP1 primary antibodies
  • Description
    Rabbit polyclonal to OSBP1
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 571-746 of Human OSBP1 (P22059).

  • Positive control
    • Jurkat, Raji and K562 whole cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab126182 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 89 kDa.

Target

  • Function
    Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability.
  • Tissue specificity
    Widely expressed.
  • Sequence similarities
    Belongs to the OSBP family.
    Contains 1 PH domain.
  • Domain
    The PH and Ala/Gly-rich domains control cholesterol binding without affecting 25-hydroxycholesterol binding.
    The second coiled-coil domain is required for interaction with the tyrosine phosphatase.
  • Cellular localization
    Cytoplasm. Golgi apparatus membrane. When bound to oxysterols, translocates to the periphery of Golgi membranes.
  • Information by UniProt
  • Database links
    see all
  • Alternative names
    • OSBP 1 antibody
    • OSBP antibody
    • OSBP1_HUMAN antibody
    • Oxysterol binding protein 1 antibody
    • Oxysterol-binding protein 1 antibody
    see all

Images

  • Western blot - Anti-OSBP1 antibody (ab126182)
    Western blot - Anti-OSBP1 antibody (ab126182)
    All lanes : Anti-OSBP1 antibody (ab126182) at 1/1000 dilution

    Lane 1 : Jurkat whole cell lysate
    Lane 2 : Raji whole cell lysate
    Lane 3 : K562 whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 89 kDa



    7.5% SDS PAGE

References

ab126182 has not yet been referenced specifically in any publications.

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