Anti-OSBP1 antibody (ab126182)
Key features and details
- Rabbit polyclonal to OSBP1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-OSBP1 antibody
See all OSBP1 primary antibodies -
Description
Rabbit polyclonal to OSBP1 -
Host species
Rabbit -
Tested applications
Suitable for: WBmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Rabbit -
Immunogen
Recombinant fragment, corresponding to a region within amino acids 571-746 of Human OSBP1 (P22059).
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Positive control
- Jurkat, Raji and K562 whole cell lysates.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
Storage buffer
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 1% BSA, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab126182 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
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WB |
1/500 - 1/3000. Predicted molecular weight: 89 kDa.
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Notes |
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WB
1/500 - 1/3000. Predicted molecular weight: 89 kDa. |
Target
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Function
Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability. -
Tissue specificity
Widely expressed. -
Sequence similarities
Belongs to the OSBP family.
Contains 1 PH domain. -
Domain
The PH and Ala/Gly-rich domains control cholesterol binding without affecting 25-hydroxycholesterol binding.
The second coiled-coil domain is required for interaction with the tyrosine phosphatase. -
Cellular localization
Cytoplasm. Golgi apparatus membrane. When bound to oxysterols, translocates to the periphery of Golgi membranes. - Information by UniProt
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Database links
- Entrez Gene: 5007 Human
- Entrez Gene: 76303 Mouse
- Entrez Gene: 100009048 Rabbit
- Entrez Gene: 365410 Rat
- Omim: 167040 Human
- SwissProt: P22059 Human
- SwissProt: Q3B7Z2 Mouse
- SwissProt: P16258 Rabbit
see all -
Alternative names
- OSBP 1 antibody
- OSBP antibody
- OSBP1_HUMAN antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (0)
ab126182 has not yet been referenced specifically in any publications.