Anti-OSBP1 antibody (ab126182)

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Overview

  • Product name

    Anti-OSBP1 antibody
    See all OSBP1 primary antibodies

  • Description

    Rabbit polyclonal to OSBP1

  • Host species

    Rabbit

  • Tested applications

    Suitable for: WBmore details

  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Rabbit

  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 571-746 of Human OSBP1 (P22059).

  • Positive control

    • Jurkat, Raji and K562 whole cell lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab126182 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 89 kDa.

Target

  • Function

    Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability.

  • Tissue specificity

    Widely expressed.

  • Sequence similarities

    Belongs to the OSBP family.
    Contains 1 PH domain.

  • Domain

    The PH and Ala/Gly-rich domains control cholesterol binding without affecting 25-hydroxycholesterol binding.
    The second coiled-coil domain is required for interaction with the tyrosine phosphatase.

  • Cellular localization

    Cytoplasm. Golgi apparatus membrane. When bound to oxysterols, translocates to the periphery of Golgi membranes.
  • Information by UniProt

  • Database links

    see all

  • Alternative names

    • OSBP 1 antibody
    • OSBP antibody
    • OSBP1_HUMAN antibody
    • Oxysterol binding protein 1 antibody
    • Oxysterol-binding protein 1 antibody
    see all

Images

  • Western blot - Anti-OSBP1 antibody (ab126182)
    Western blot - Anti-OSBP1 antibody (ab126182)
    All lanes : Anti-OSBP1 antibody (ab126182) at 1/1000 dilution

    Lane 1 : Jurkat whole cell lysate
    Lane 2 : Raji whole cell lysate
    Lane 3 : K562 whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 89 kDa



    7.5% SDS PAGE

References

ab126182 has not yet been referenced specifically in any publications.

Publishing research using ab126182? Please let us know so that we can cite the reference in this datasheet.

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