Key features and details
- Rabbit polyclonal to OSBP1 - N-terminal
- Suitable for: IP
- Reacts with: Human
- Isotype: IgG
Product nameAnti-OSBP1 antibody - N-terminal
See all OSBP1 primary antibodies
DescriptionRabbit polyclonal to OSBP1 - N-terminal
Tested applicationsSuitable for: IPmore details
Unsuitable for: WB
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rabbit, Dog, Chimpanzee, Rhesus monkey, Orangutan
- 293T whole cell lysate.
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We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7
Preservative: 0.09% Sodium azide
Constituent: 99% Tris citrate/phosphate
pH 7 to 8
Concentration information loading...
PurityImmunogen affinity purified
Purification notesab192990 was affinity purified using an epitope specific to OSBP1 immobilized on solid support.
Our Abpromise guarantee covers the use of ab192990 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IP||Use at 2-10 µg/mg of lysate.|
FunctionBinds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25-hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability.
Tissue specificityWidely expressed.
Sequence similaritiesBelongs to the OSBP family.
Contains 1 PH domain.
DomainThe PH and Ala/Gly-rich domains control cholesterol binding without affecting 25-hydroxycholesterol binding.
The second coiled-coil domain is required for interaction with the tyrosine phosphatase.
Cellular localizationCytoplasm. Golgi apparatus membrane. When bound to oxysterols, translocates to the periphery of Golgi membranes.
- Information by UniProt
- OSBP 1 antibody
- OSBP antibody
- OSBP1_HUMAN antibody
ab192990 has been referenced in 1 publication.
- Civra A et al. 25-Hydroxycholesterol and 27-hydroxycholesterol inhibit human rotavirus infection by sequestering viral particles into late endosomes. Redox Biol 19:318-330 (2018). PubMed: 30212801