OSMI-1, O-GlcNAc transferase (OGT) inhibitor (ab235455)

Overview

  • Product name

    OSMI-1, O-GlcNAc transferase (OGT) inhibitor
  • Description

    Potent, cell-permeable, O-GlcNAc transferase (OGT) inhibitor.
  • Biological description

    Potent, cell-permeable, O-GlcNAc transferase (OGT) inhibitor. Inhibits protein O-GlcNAcylation in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans.

  • Purity

    > 98%
  • CAS Number

    1681056-61-0
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    αR-α-[[(1,2-Dihydro-2-oxo-6-quinolinyl)sulfonyl]amino]-N-(2-furanylmethyl)-2-methoxy-N-(2-thienylmethyl)-benzeneacetamide

  • Molecular weight

    563.64
  • Molecular formula

    C28H25N3O6S2
  • PubChem identifier

    118634407
  • Storage instructions

    Shipped at Room Temperature. Store at -20°C. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    DMSO ~20 mg/mL

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    COC1=CC=CC=C1C(C(=O)N(CC2=CC=CO2)CC3=CC=CS3)NS(=O)(=O)C4=CC5=C(C=C4)NC(=O)C=C5
  • Source

    Synthetic

References

This product has been referenced in:

  • Ortiz-Meoz RF  et al. A small molecule that inhibits OGT activity in cells. ACS Chem Biol 10:1392-7 (2015). Read more (PubMed: 25751766) »
  • Angelova M  et al. Inhibition of O-Linked N-Acetylglucosamine Transferase Reduces Replication of Herpes Simplex Virus and Human Cytomegalovirus. J Virol 89:8474-83 (2015). Read more (PubMed: 26041297) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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