Overview

  • Product name
  • Description
    Goat polyclonal to OSMR
  • Host species
    Goat
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide:

    QIHGEQLDPHVT

    by a Cysteine residue linker, corresponding to internal sequence amino acids 185-196 of Human OSMR (NP_003990.1).

  • Positive control
    • HeLa, A549 and U937 lysates.

Properties

Applications

Our Abpromise guarantee covers the use of ab156939 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 125 kDa (predicted molecular weight: 111 kDa).

Target

  • Function
    Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events.
  • Tissue specificity
    Expressed at relatively high levels in all neural cells as well as fibroblast, epithelial and a variety of tumor cell lines.
  • Involvement in disease
    Amyloidosis, primary localized cutaneous, 1 (PLCA1) [MIM:105250]: A primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening that may be exacerbated by chronic scratching and rubbing. Primary localized cutaneous amyloidosis is often divided into macular and lichen subtypes although many affected individuals often show both variants coexisting. Lichen amyloidosis characteristically presents as a pruritic eruption of grouped hyperkeratotic papules with a predilection for the shins, calves, ankles and dorsa of feet and thighs. Papules may coalesce to form hyperkeratotic plaques that can resemble lichen planus, lichen simplex or nodular prurigo. Macular amyloidosis is characterized by small pigmented macules that may merge to produce macular hyperpigmentation, sometimes with a reticulate or rippled pattern. In macular and lichen amyloidosis, amyloid is deposited in the papillary dermis in association with grouped colloid bodies, thought to represent degenerate basal keratinocytes. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Sequence similarities
    Belongs to the type I cytokine receptor family. Type 2 subfamily.
    Contains 4 fibronectin type-III domains.
  • Domain
    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.
  • Cellular localization
    Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • IL-31 receptor subunit beta antibody
    • IL-31R subunit beta antibody
    • IL-31R-beta antibody
    • IL-31RB antibody
    • Interleukin-31 receptor subunit beta antibody
    • MGC140467 antibody
    • MGC150626 antibody
    • MGC150627 antibody
    • MGC75127 antibody
    • Oncostatin M receptor antibody
    • Oncostatin M specific receptor subunit beta antibody
    • Oncostatin M-specific receptor, beta antibody
    • Oncostatin-M-specific receptor subunit beta antibody
    • Osmr antibody
    • OSMR_HUMAN antibody
    • OSMRB antibody
    see all

Images

  • All lanes : Anti-OSMR antibody (ab156939) at 0.3 µg/ml

    Lane 1 : U937 cell lysate in RIPA buffer
    Lane 2 : A431 cell lysate in RIPA buffer
    Lane 3 : HepG2 cell lysate in RIPA buffer

    Lysates/proteins at 35 µg per lane.

    Predicted band size: 111 kDa



    Detected by chemiluminescence.

References

ab156939 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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