Key features and details
- Rabbit polyclonal to OSMR
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-OSMR antibody
See all OSMR primary antibodies
DescriptionRabbit polyclonal to OSMR
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Predicted to work with: Rabbit, Horse, Guinea pig, Dog
- WB: 721_B cell lysate; Human lung tumor lysate.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferPreservative: 0.09% Sodium azide
Constituents: PBS, 2% Sucrose
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab85575 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use a concentration of 1 µg/ml. Predicted molecular weight: 111 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.|
FunctionAssociates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events.
Tissue specificityExpressed at relatively high levels in all neural cells as well as fibroblast, epithelial and a variety of tumor cell lines.
Involvement in diseaseAmyloidosis, primary localized cutaneous, 1 (PLCA1) [MIM:105250]: A primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening that may be exacerbated by chronic scratching and rubbing. Primary localized cutaneous amyloidosis is often divided into macular and lichen subtypes although many affected individuals often show both variants coexisting. Lichen amyloidosis characteristically presents as a pruritic eruption of grouped hyperkeratotic papules with a predilection for the shins, calves, ankles and dorsa of feet and thighs. Papules may coalesce to form hyperkeratotic plaques that can resemble lichen planus, lichen simplex or nodular prurigo. Macular amyloidosis is characterized by small pigmented macules that may merge to produce macular hyperpigmentation, sometimes with a reticulate or rippled pattern. In macular and lichen amyloidosis, amyloid is deposited in the papillary dermis in association with grouped colloid bodies, thought to represent degenerate basal keratinocytes. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins. Note=The disease is caused by mutations affecting the gene represented in this entry.
Sequence similaritiesBelongs to the type I cytokine receptor family. Type 2 subfamily.
Contains 4 fibronectin type-III domains.
DomainThe WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.
- Information by UniProt
- IL-31 receptor subunit beta antibody
- IL-31R subunit beta antibody
- IL-31R-beta antibody
Anti-OSMR antibody (ab85575) at 1 µg/ml (in 5% skim milk / PBS buffer) + 721_B cell lysate at 10 µg
HRP conjugated anti-Rabbit IgG at 1/50000 dilution
Predicted band size: 111 kDa
Observed band size: 110 kDa why is the actual band size different from the predicted?
Additional bands at: <40 kDa. We are unsure as to the identity of these extra bands.
Gel concentration: 6-18%
All lanes : Anti-OSMR antibody (ab85575) at 3 µg/ml
Lane 1 : Human lung tumor lysate
Lane 2 : Human liver tumor lysate
Lysates/proteins at 25 µg per lane.
Predicted band size: 111 kDa
Additional bands at: 40 kDa (possible isoform)
Western blot analysis labeling OSMR with ab85575.
ab85575 has not yet been referenced specifically in any publications.