Anti-Osteocalcin antibody (ab198228)
Key features and details
- Rabbit polyclonal to Osteocalcin
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-Osteocalcin antibody
See all Osteocalcin primary antibodies -
Description
Rabbit polyclonal to Osteocalcin -
Host species
Rabbit -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human -
Immunogen
Synthetic peptide corresponding to Human Osteocalcin. (Near the C terminal; NP_954642.1).
Database link: P02818 -
Positive control
- Human breast cancer and ovarian cancer tissues.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS -
Concentration information loading... -
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Recombinant Protein
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Related Products
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab198228 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P | (2) |
1/50 - 1/200.
|
| Notes |
|---|
|
IHC-P
1/50 - 1/200. |
Target
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Function
Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. -
Sequence similarities
Belongs to the osteocalcin/matrix Gla protein family.
Contains 1 Gla (gamma-carboxy-glutamate) domain. -
Post-translational
modificationsGamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation. These residues are essential for the binding of calcium. -
Cellular localization
Secreted. - Information by UniProt
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Database links
- Entrez Gene: 632 Human
- Omim: 112260 Human
- SwissProt: P02818 Human
- Unigene: 654541 Human
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Alternative names
- BGLAP antibody
- BGP antibody
- Bone gamma carboxyglutamate (gla) protein antibody
see all
Images
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Osteocalcin antibody (ab198228)
Immunohistochemical analysis of paraffin-embedded Human ovarian cancer tissue labeling Osteocalcin with ab198228 at 1/60 dilution.
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Osteocalcin antibody (ab198228)Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue labeling Osteocalcin with ab198228 at 1/60 dilution.
Datasheets and documents
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SDS download
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Datasheet download
References (4)
ab198228 has been referenced in 4 publications.
- Wu CY et al. Vapor-phased fabrication and modulation of cell-laden scaffolding materials. Nat Commun 12:3413 (2021). PubMed: 34099701
- Shen J et al. EGFL6 regulates angiogenesis and osteogenesis in distraction osteogenesis via Wnt/ß-catenin signaling. Stem Cell Res Ther 12:415 (2021). PubMed: 34294121
- Zhang ZZ et al. 3D printed poly(e-caprolactone) scaffolds function with simvastatin-loaded poly(lactic-co-glycolic acid) microspheres to repair load-bearing segmental bone defects. Exp Ther Med 17:79-90 (2019). PubMed: 30651767
- Wang L et al. Periosteal Mesenchymal Progenitor Dysfunction and Extraskeletally-Derived Fibrosis Contribute to Atrophic Fracture Nonunion. J Bone Miner Res 34:520-532 (2019). PubMed: 30602062