Key features and details
- Goat polyclonal to Osteopontin
- Reacts with: Mouse
- Isotype: IgG
- Research with confidence – consistent and reproducible results with every batch
- Long-term and scalable supply – powered by recombinant technology for fast production
- Success from the first experiment – confirmed specificity through extensive validation
- Ethical standards compliant – production is animal-free
Product nameAnti-Osteopontin antibody
See all Osteopontin primary antibodies
DescriptionGoat polyclonal to Osteopontin
Species reactivityReacts with: Mouse
Recombinant full length protein (Mouse) expressed in NSO cells.
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Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferConstituents: PBS, 5% Trehalose
Concentration information loading...
PurityImmunogen affinity purified
FunctionBinds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction.
Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity.
Tissue specificityBone. Found in plasma.
Sequence similaritiesBelongs to the osteopontin family.
modificationsExtensively phosphorylated on clustered serine residues.
N- and O-glycosylated.
Phosphorylation sites are present in the extracelllular medium.
- Information by UniProt
- BNSP antibody
- Bone sialoprotein 1 antibody
- Bone sialoprotein I antibody
ab11503 has been referenced in 10 publications.
- Xin D et al. MSCs-extracellular vesicles attenuated neuroinflammation, synapse damage and microglial phagocytosis after hypoxia-ischemia injury by preventing osteopontin expression. Pharmacol Res 164:105322 (2021). PubMed: 33279596
- Giopanou I et al. Osteopontin drives KRAS-mutant lung adenocarcinoma. Carcinogenesis 41:1134-1144 (2020). PubMed: 31740923
- Hou YC et al. Tailoring of cardiovascular stent material surface by immobilizing exosomes for better pro-endothelialization function. Colloids Surf B Biointerfaces 189:110831 (2020). PubMed: 32058252
- Sharon Y et al. Tumor-derived osteopontin reprograms normal mammary fibroblasts to promote inflammation and tumor growth in breast cancer. Cancer Res 75:963-73 (2015). IHC-P ; Mouse . PubMed: 25600648
- Shibasaki M et al. Pitavastatin Reduces Inflammation in Atherosclerotic Plaques in Apolipoprotein E-Deficient Mice with Late Stage Renal Disease. PLoS One 10:e0138047 (2015). PubMed: 26367531
- Ge X et al. Evodiamine Attenuates PDGF-BB-Induced Migration of Rat Vascular Smooth Muscle Cells through Activating PPAR?. Int J Mol Sci 16:28180-93 (2015). PubMed: 26703570
- Deangelis T et al. Growth of V-SRC-transformed cells in serum-free medium through the induction of growth factors. J Cell Physiol : (2012). PubMed: 23254450
- Redding KM et al. Transgenic mice expressing an intracellular fluorescent fusion of angiotensin II demonstrate renal thrombotic microangiopathy and elevated blood pressure. Am J Physiol Heart Circ Physiol 298:H1807-18 (2010). WB ; Mouse . PubMed: 20363893
- Yang X et al. Bone morphogenic protein 2 induces Runx2 and osteopontin expression in human aortic valve interstitial cells: role of Smad1 and extracellular signal-regulated kinase 1/2. J Thorac Cardiovasc Surg 138:1008-15 (2009). PubMed: 19664780
- Aikawa E et al. Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease. Circulation 115:377-86 (2007). IHC-Fr ; Mouse . PubMed: 17224478