Osthole, anti-inflammatory and antitumor activities  (ab143140)

Overview

  • Product name

    Osthole, anti-inflammatory and antitumor activities 
  • Description

    Bioactive coumarin. Anti-inflammatory and antitumor activity.
  • Biological description

    Bioactive coumarin. Anti-inflammatory and antitumor activity. Phosphoinositide inhibitor and calcium channel blocker (IC50 = 4 μM). Suppresses NFκB activity to induce cell-cycle arrest and apoptosis in cancer cells. Anticoagulant, anti-inflammatory, neuroprotective and antitumor agent. Active in vivo and in vitro.
  • Purity

    > 99%
  • CAS Number

    484-12-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    7-Methoxy-8-(3-methylbut-2-enyl)chromen-2-one
  • Molecular weight

    244.29
  • Molecular formula

    C15H16O3
  • PubChem identifier

    10228
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM (with warming) and in ethanol to 100 mM (with warming)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1(=CC=C2C(=C1CC=C(C)C)OC(C=C2)=O)OC
  • Source

    Cnidium monnieri (L.) Cusson

  • Research areas

References

This product has been referenced in:

  • Zhang L  et al. Growth inhibition and apoptosis induced by osthole, a natural coumarin, in hepatocellular carcinoma. PLoS One 7:e37865 (2012). Read more (PubMed: 22662241) »
  • Wu SN  et al. Inhibitory effect of the plant-extract osthole on L-type calcium current in NG108-15 neuronal cells. Biochem Pharmacol 63:199-206 (2002). Read more (PubMed: 11841794) »
  • Ko FN  et al. Inhibition of platelet thromboxane formation and phosphoinositides breakdown by osthole from Angelica pubescens. Thromb Haemost 62:996-9 (1989). Read more (PubMed: 2556815) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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