Overview

  • Product name

  • Description

    Rabbit polyclonal to OSTM1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 1-284 of Human OSTM1 (NP_054747).

  • Positive control

    • Raji and HL60 whole cell lysates.
  • General notes

    Keep as concentrated solution.

Properties

Applications

Our Abpromise guarantee covers the use of ab126209 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 37 kDa.

Target

  • Function

    Required for osteoclast and melanocyte maturation and function.
  • Involvement in disease

    Defects in OSTM1 are the cause of osteopetrosis autosomal recessive type 5 (OPTB5) [MIM:259720]; also called infantile malignant osteopetrosis 3. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. OPTB5 patients manifest primary central nervous system involvement in addition to the classical stigmata of severe bone sclerosis, growth failure, anemia, thrombocytopenia and visual impairment with optic atrophy.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Chloride channel 7 beta subunit antibody
    • GAIP-interacting protein N terminus antibody
    • GIPN antibody
    • GL antibody
    • Grey lethal osteopetrosis antibody
    • HSPC019 antibody
    • OPTB5 antibody
    • Osteopetrosis-associated transmembrane protein 1 antibody
    • Ostm1 antibody
    • OSTM1_HUMAN antibody
    • OTTHUMP00000016938 antibody
    • OTTHUMP00000196342 antibody
    see all

Images

  • All lanes : Anti-OSTM1 antibody (ab126209) at 1/1000 dilution

    Lane 1 : Raji whole cell lysate
    Lane 2 : HL60 whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size: 37 kDa



    10% SDS PAGE

References

ab126209 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

1-2 of 2 Abreviews or Q&A

Abreviews
Application
Western blot
Sample
Human Tissue lysate - whole (brain)
Gel Running Conditions
Reduced Denaturing (12%)
Loading amount
50 µg
Specification
brain
Blocking step
Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 22°C

Abcam user community

Verified customer

Submitted Apr 03 2018

Application
Western blot
Loading amount
20 µg
Gel Running Conditions
Reduced Denaturing (10%)
Sample
Human Cell lysate - whole cell (HEK293)
Specification
HEK293
Treatment
siRNA specific to OSTM1
Blocking step
BSA as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 3% · Temperature: 23°C

Abcam user community

Verified customer

Submitted Mar 28 2014

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