Overview

  • Product name

  • Description

    Rabbit polyclonal to OSTM1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human OSTM1 aa 32-88 conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Sequence:

    ALPFGSSPHRVFHDLLSEQQLLEVEDLSLSLLQGGGLGPLSLPPDLPDLD PECRELL


    Database link: Q86WC4

  • Positive control

    • Rat kidney tissue. Human colon carcinoma lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab203629 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500.

When using a fluorescent probe please use dilutions of 1/50 - 1/200.

WB 1/100 - 1/1000. Predicted molecular weight: 37 kDa.

Target

  • Function

    Required for osteoclast and melanocyte maturation and function.
  • Involvement in disease

    Defects in OSTM1 are the cause of osteopetrosis autosomal recessive type 5 (OPTB5) [MIM:259720]; also called infantile malignant osteopetrosis 3. Osteopetrosis is a rare genetic disease characterized by abnormally dense bone, due to defective resorption of immature bone. The disorder occurs in two forms: a severe autosomal recessive form occurring in utero, infancy, or childhood, and a benign autosomal dominant form occurring in adolescence or adulthood. OPTB5 patients manifest primary central nervous system involvement in addition to the classical stigmata of severe bone sclerosis, growth failure, anemia, thrombocytopenia and visual impairment with optic atrophy.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Chloride channel 7 beta subunit antibody
    • GAIP-interacting protein N terminus antibody
    • GIPN antibody
    • GL antibody
    • Grey lethal osteopetrosis antibody
    • HSPC019 antibody
    • OPTB5 antibody
    • Osteopetrosis-associated transmembrane protein 1 antibody
    • Ostm1 antibody
    • OSTM1_HUMAN antibody
    • OTTHUMP00000016938 antibody
    • OTTHUMP00000196342 antibody
    see all

Images

  • Anti-OSTM1 antibody (ab203629) at 1/200 dilution + human colon carcinoma lysates

    Secondary
    Goat Anti-Rabbit IgG Antibody (H+L), HRP Conjugated at 1/3000 dilution

    Predicted band size: 37 kDa

  • Immunohistochemical analysis of formalin-fixed paraffin-embedded rat kidney tissue labeling OSTM1 with ab203629 at 1/200 dilution. DAB staining.

References

ab203629 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab203629.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up