Question (35826) | Anti-Otx1 + Otx2 antibody - ChIP Grade (ab21990)

Go to datasheet (ab21990)

Question

Phoned because the target of ab21990 has changed and is now unsure about their data.

Answer

Thank you for contacting us.

I am sorry that you have found this product unsatisfactory following its recent target refinement. As we discussed on the phone the sequence for ab21990 is shared by both OTX1 and OTX2. It was because of this that we have changed the targets.

We have other products which has been guaranteed to work in WB and ICH on human tissue. One such product is ab76748. According to information that I have recieved form the lab, this antibody is specific to Otx2 only with no cross reactivity with Otx1. The immunogenic peptide was selected from specific domains of Otx2.


Another product I would like to mention is ab92326. The immunogen for this OTX2 antibody shares 81% identity with OTX1, so the antibody is not predicted to cross-react with OTX1. However, it is not guaranteed without testing

I hope this information is helpful to you. Please do not hesitate to contact us if you need any more advice or information.

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