Overview

Description

  • Nature
    Synthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab156847 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Otx2 antibody (ab76748)

  • Form
    Liquid

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium azide
    Constituents: PBS, 0.12% BSA

General Info

  • Alternative names
    • CPHD6
    • Homeobox protein OTX2
    • MCOPS 5
    • MCOPS5
    • MGC45000
    • Orthodenticle 2
    • Orthodenticle homeobox 2
    • Orthodenticle homolog 2
    • Orthodenticle homolog 2 (Drosophila)
    • Orthodenticle2
    • Otx 2
    • otx2
    • OTX2_HUMAN
    see all
  • Function
    Probably plays a role in the development of the brain and the sense organs. Can bind to the BCD target sequence (BTS): 5'-TCTAATCCC-3'.
  • Tissue specificity
    Expressed in brain.
  • Involvement in disease
    Defects in OTX2 are the cause of microphthalmia syndromic type 5 (MCOPS5) [MIM:610125]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Up to 80% of cases of microphthalia occur in association with syndromes that include non-ocular abnormalities. MCOPS5 patients manifest unilateral or bilateral microphthalmia/clinical anophthalmia and variable additional features including coloboma, microcornea, cataract, retinal dystrophy, hypoplasia or agenesis of the optic nerve, agenesis of the corpus callosum, developmental delay, joint laxity, hypotonia, and seizures.
  • Sequence similarities
    Belongs to the paired homeobox family. Bicoid subfamily.
    Contains 1 homeobox DNA-binding domain.
  • Developmental stage
    Embryo.
  • Cellular localization
    Nucleus.
  • Information by UniProt

References

ab156847 has not yet been referenced specifically in any publications.

Customer reviews and Q&As


We have added the specific blocking peptide used to produce ab76748 to the catalog. A link for the blocking peptide is given below:
ab156847: https://www.abcam.com/otx2-peptide-ab156847.html

Our blocking protocol is given through the ...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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