Overview

  • Product name

    Oxcarbazepine, Sodium channel inhibitor
  • Description

    Sodium channel inhibitor
  • Biological description

    Sodium channel inhibitor. A structural derivative of carbamazepine. A prodrug which is activated to eslicarbazepine in vivo. Shows anticonvulsant activity.
  • Purity

    > 98%
  • CAS Number

    28721-07-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-Oxo-6H-benzo[b][1]benzazepine-11-carboxamide
  • Molecular weight

    252.30
  • Molecular formula

    C15H12N2O2
  • PubChem identifier

    34312
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1C2=CC=CC=C2N(C3=CC=CC=C3C1=O)C(=O)N
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Fortuna A  et al. A chiral liquid chromatography method for the simultaneous determination of oxcarbazepine, eslicarbazepine, R-licarbazepine and other new chemical derivatives BIA 2-024, BIA 2-059 and BIA 2-265, in mouse plasma and brain. Biomed Chromatogr 26:384-92 (2012). Read more (PubMed: 21780155) »
  • Alfaro-Rodríguez A  et al. Effects of oxcarbazepine on monoamines content in hippocampus and head and body shakes and sleep patterns in kainic acid-treated rats. Metab Brain Dis 26:213-20 (2011). Read more (PubMed: 21789566) »
  • Ayala-Guerrero F  et al. Effect of oxcarbazepine on sleep architecture. Epilepsy Behav 15:287-90 (2009). Read more (PubMed: 19379835) »

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