Overview

  • Product name

  • Description

    Rabbit polyclonal to OXCT1/SCOT
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: IP
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Rat
  • Immunogen

    Synthetic peptide within Human OXCT1/SCOT aa 25-75. The exact sequence is proprietary.
    Database link: P55809

  • Positive control

    • WB: HeLa, HEK-293T, Jurkat, TCMK-1 and NIH/3T3 whole cell lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab241221 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/10000 - 1/25000.
  • Application notes
    Is unsuitable for IP.
  • Target

    • Function

      Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
    • Tissue specificity

      Abundant in heart, followed in order by kidney, brain, and muscle, whereas in liver it is undetectable; also detectable in leukocytes and fibroblasts.
    • Pathway

      Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.
    • Involvement in disease

      Succinyl-CoA:3-oxoacid CoA transferase deficiency
    • Sequence similarities

      Belongs to the 3-oxoacid CoA-transferase family.
    • Cellular localization

      Mitochondrion matrix.
    • Information by UniProt
    • Database links

    • Alternative names

      • 3 oxoacid CoA transferase 1 antibody
      • 3-oxoacid CoA-transferase 1 antibody
      • EC 2.8.3.5 antibody
      • OTTHUMP00000120012 antibody
      • OTTHUMP00000221550 antibody
      • OXCT antibody
      • Oxct1 antibody
      • SCOT antibody
      • Scot S antibody
      • Scot-S antibody
      • SCOT1_HUMAN antibody
      • Somatic type succinyl CoA:3 oxoacid CoA transferase antibody
      • Somatic-type succinyl-CoA:3-oxoacid CoA-transferase antibody
      • Succinyl CoA:3 ketoacid CoA transferase antibody
      • Succinyl CoA:3 ketoacid coenzyme A transferase 1 mitochondrial antibody
      • Succinyl CoA:3 oxoacid CoA transferase antibody
      • Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial antibody
      see all

    Images

    • All lanes : Anti-OXCT1/SCOT antibody (ab241221) at 0.04 µg/ml

      Lane 1 : HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate
      Lane 2 : HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate
      Lane 3 : Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate
      Lane 4 : TCMK-1 (mouse kidney epithelial cell line) whole cell lysate
      Lane 5 : NIH/3T3 (mouse embryo fibroblast cell line) whole cell lysate

      Lysates/proteins at 15 µg per lane.

      Exposure time: 3 minutes


      Lysates prepared using NETN lysis buffer.

    References

    ab241221 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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