Overview

  • Product name

  • Description

    Mouse polyclonal to OXCT1/SCOT
  • Host species

    Mouse
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Full length protein corresponding to Human OXCT1/SCOT. (NP_000427.1)

  • Positive control

    • WB: OXCT1/SCOT transfected 293T cell lysate.
  • General notes

    Protein previously labeled as OXCT1.

Properties

Applications

Our Abpromise guarantee covers the use of ab70413 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 56 kDa.

Target

  • Function

    Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.
  • Tissue specificity

    Abundant in heart, followed in order by kidney, brain, and muscle, whereas in liver it is undetectable; also detectable in leukocytes and fibroblasts.
  • Pathway

    Ketone metabolism; succinyl-CoA degradation; acetoacetyl-CoA from succinyl-CoA: step 1/1.
  • Involvement in disease

    Succinyl-CoA:3-oxoacid CoA transferase deficiency
  • Sequence similarities

    Belongs to the 3-oxoacid CoA-transferase family.
  • Cellular localization

    Mitochondrion matrix.
  • Information by UniProt
  • Database links

  • Alternative names

    • 3 oxoacid CoA transferase 1 antibody
    • 3-oxoacid CoA-transferase 1 antibody
    • EC 2.8.3.5 antibody
    • OTTHUMP00000120012 antibody
    • OTTHUMP00000221550 antibody
    • OXCT antibody
    • Oxct1 antibody
    • SCOT antibody
    • Scot S antibody
    • Scot-S antibody
    • SCOT1_HUMAN antibody
    • Somatic type succinyl CoA:3 oxoacid CoA transferase antibody
    • Somatic-type succinyl-CoA:3-oxoacid CoA-transferase antibody
    • Succinyl CoA:3 ketoacid CoA transferase antibody
    • Succinyl CoA:3 ketoacid coenzyme A transferase 1 mitochondrial antibody
    • Succinyl CoA:3 oxoacid CoA transferase antibody
    • Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial antibody
    see all

Images

  • All lanes : Anti-OXCT1/SCOT antibody (ab70413) at 1/500 dilution

    Lane 1 : OXCT1/SCOT transfected 293T cell lysate
    Lane 2 : Non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    All lanes : Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size: 56 kDa
    Observed band size: 50 kDa
    why is the actual band size different from the predicted?

References

This product has been referenced in:

  • Karwi QG  et al. Targeting the glucagon receptor improves cardiac function and enhances insulin sensitivity following a myocardial infarction. Cardiovasc Diabetol 18:1 (2019). Read more (PubMed: 30626440) »
See 1 Publication for this product

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