Oxybutynin (Ditropan), muscarinic receptor antagonist (ab143072)

Overview

  • Product name

    Oxybutynin (Ditropan), muscarinic receptor antagonist
  • Description

    Potent, competitive muscarinic receptor antagonist
  • Biological description

    Potent, competitive muscarinic receptor antagonist (IC50 = 5.4 nm). Spasmolytic effects on bladder smooth muscle. Active in vivo. Blood-brain barrier permeable.
  • Purity

    > 99%
  • CAS Number

    5633-20-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    4-(Diethylamino)but-2-ynyl 2-cyclohexyl-2-hydroxy-2-phenylacetate
  • Molecular weight

    357.49
  • Molecular formula

    C22H31NO3
  • PubChem identifier

    4634
  • Storage instructions

    Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1(=CC=CC=C1)C(C2CCCCC2)(C(=O)OCC#CCN(CC)CC)O
  • Source

    Synthetic

References

This product has been referenced in:

  • Nagabukuro H  et al. Comparative analysis of the effects of antimuscarinic agents on bladder functions in both nonhuman primates and rodents. J Pharmacol Exp Ther 338:220-7 (2011). Read more (PubMed: 21459965) »
  • Yamamoto S  et al. Effect of oxybutynin and imidafenacin on central muscarinic receptor occupancy and cognitive function: a monkey PET study with [(11)C](+)3-MPB. Neuroimage 58:1-9 (2011). Read more (PubMed: 21712096) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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