Anti-Oxytocin-neurophysin 1 antibody (ab2078)

Reviews (2)Q&A (3)References (14)

Key features and details

  • Rabbit polyclonal to Oxytocin-neurophysin 1
  • Reacts with: Mouse, Rat, Sheep, Rabbit, Human, Pig
  • Isotype: IgG

Overview

  • Product name

    Anti-Oxytocin-neurophysin 1 antibody
    See all Oxytocin-neurophysin 1 primary antibodies

  • Description

    Rabbit polyclonal to Oxytocin-neurophysin 1

  • Host species

    Rabbit

  • Specificity

    Less than 1% reactivity to vasopressin.

  • Species reactivity

    Reacts with: Mouse, Rat, Sheep, Rabbit, Human, Pig

  • Immunogen

    Other Immunogen Type corresponding to Oxytocin-neurophysin 1. Immunogen: oxytocin-thyroglobulin

  • General notes

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

Target

  • Relevance

    Neurophysin 1 specifically binds oxytocin. Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Oxytocin is a posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. Oxytocin contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions.

  • Cellular localization

    Secreted

  • Database links

    see all

  • Alternative names

    • MGC126890 antibody
    • MGC126892 antibody
    • Neurophysin 1 antibody
    • Neurophysin I antibody
    • Ocytocin antibody
    • OT antibody
    • OT NPI antibody
    • OXT antibody
    • Oxytocin Neurophysin preproprotein antibody
    • Oxytocin prepro (neurophysin I) antibody
    • Oxytocin prepropeptide antibody
    • Oxytocin-neurophysin 1 antibody
    see all

References (14)

Publishing research using ab2078? Please let us know so that we can cite the reference in this datasheet.

ab2078 has been referenced in 14 publications.

  • Ogata K  et al. Lavender Oil Reduces Depressive Mood in Healthy Individuals and Enhances the Activity of Single Oxytocin Neurons of the Hypothalamus Isolated from Mice: A Preliminary Study. Evid Based Complement Alternat Med 2020:5418586 (2020). PubMed: 32733584
  • Song TJ  et al. Altered Behaviors and Impaired Synaptic Function in a Novel Rat Model With a Complete Shank3 Deletion. Front Cell Neurosci 13:111 (2019). PubMed: 30971895
  • Mohan S  et al. Oxytocin is present in islets and plays a role in beta-cell function and survival. Peptides 100:260-268 (2018). IF . PubMed: 29274352
  • Zhang B  et al. Central insulin action induces activation of paraventricular oxytocin neurons to release oxytocin into circulation. Sci Rep 8:10415 (2018). PubMed: 29991705
  • Dai D  et al. Direct Involvement of Androgen Receptor in Oxytocin Gene Expression: Possible Relevance for Mood Disorders. Neuropsychopharmacology 42:2064-2071 (2017). PubMed: 28447621
View all Publications for this product

Customer reviews and Q&As

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1-3 of 3 Q&A

Question

Dear ladies and gentleman, I am interestet in the anti-OT and anti-AVP antibodies from this paper: PLoS One. 2011;6(8):e23362. Epub 2011 Aug 17. Oxytocin and vasopressin involved in restraint water-immersion stress mediated by oxytocin receptor and vasopressin 1b receptor in rat brain. Zhao DQ, Ai HB. unfortunately in the refference list of all of your antibodies i couldn´t find this paper, although they had their antibodies from your company. can you please help me?

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Answer

Thank you for your inquiry. Unfortunately, we are unable to track down the particular antibodies the authors used when it is not specifically mentioned in the paper. However, the following antibodies might have been used: ab39363: anti-Vasopressin (AVP), guaranteed to work in immunohistochemistry (PFA perfusion fixed frozen sections and frozen sections, IHC-FoFr, IHC-Fr) on rat. Click here (or use the following: https://www.abcam.com/index.html?datasheet=39363). ab2078: anti-Oxytocin, guaranteed to work in RIA and immunohistochemistry (PFA perfusion fixed frozen sections and paraffin-embedded sections, IHC-FoFr, IHC-P) on rat. Click here (or use the following: https://www.abcam.com/index.html?datasheet=2078). ab11143: anti-Oxytocin, guaranteed to work in immunohistochemistry (frozen sections, IHC-Fr) on rat. Click here (or use the following: https://www.abcam.com/index.html?datasheet=11143). ab78364: anti-Oxytocin, guaranteed to work in ELISA and immunohistochemistry (PFA perfusion fixed frozen sections and paraffin-embedded sections, IHC-FoFr, IHC-P) on rat. Click here (or use the following: https://www.abcam.com/index.html?datasheet=78364). We are happy to reassure you that all of our products are covered by our Abpromise, which guarantees that the product will work in the applications and species specified on the datasheet, or we will offer a replacement, credit, or refund within 6 months of purchase. If the product is to be used in an untested species or application, you may be eligible for our testing discount program if the antibody has not yet been purchased. Please contact our Scientific Support team by replying to this email prior to purchase for more information. I hope this information is helpful. Please do not hesitate to contact us again with any other questions.

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Question

I am setting up an RIA to measure oxytocin in rabbit serum and thought your ab 2078 would work. On your website it is listed as having been tested for RIA, do you have a protocol available? Any information regarding this application of ab2078 would be appreciated.

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Answer

Thank you for your enquiry. I am sorry but we do not have an online RIA protocol. However, I would like to recommmend the following resources: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=716433&dopt=Abstract http://www.phoenixpeptide.com/qcdata/RIK/protocol10-1280_p.pdf http://faculty.washington.edu/jwingfie/protocols.html I hope this information helps, please do not hesitate to contact us if you need any more advice or information.

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Question

Thank you for your quick answer. I know that sometimes antibodies against vasopressin and oxytocin are using for immunostaining of vasotocin and isotocin. I would like to ask you if it's possible to use your antibodies ab8745 (anti-vasopressin) or ab2078 (anti- oxytocin) for vasotocin or isotocin staining? Could you inform me about cross-reaction of ab8745 and ab2078 with vasotocin or isotocin, please.I will be very grateful for your help.

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Answer

Thank you for your enquiry regarding our antibodies ab2078 and ab8745. Unfortunately we do not have any further information regarding their cross reactivity with vasotocin or isotocin, this has not been tested in our laboratories. I'm very sorry I couldn't help you more on this occasion,

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