Key features and details
- Cell-permeable p53 inhibitor
- CAS Number: 389850-21-9
- Purity: > 98%
- Soluble in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
Product namep-Nitropifithrin-alpha, p53 inhibitor
DescriptionCell-permeable p53 inhibitor
Cell-permeable p53 inhibitor. Pifithrin-α (ab120478) analog and prodrug. Shows more potent antiapoptotic effects than pifithrin-α. Shows antiobesogenic and hepatoprotective effects in vivo.
It is important to note that this product has been reported to be unstable under a variety of conditions. In addition to being unstable to light and air after extended periods of time, this product is extremely unstable in polar solvents such as DMSO. Within 6 hours a DMSO solution had been found to be completely converted into the tricyclic material. We therefore recommend this material is only stored as the solid form at -20°C (or below), with the exclusion of light and air, and any solutions are made up fresh and used immediately.
Chemical name1-(4-Nitrophenyl)-2-(4,5,6,7-tetrahydro-2-imino-3(2H)-benzothiazolyl)ethanone hydrobromide
Storage instructionsStore at -20°C. Please see notes section. Store In the Dark. Store under desiccating conditions. This product is air and light sensitive and impurities can occur as a result of air oxidation or due to metabolism by microbes.
Solubility overviewSoluble in DMSO to 100 mM
Unstable; make up solutions fresh and use immediately.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab145873 has not yet been referenced specifically in any publications.