Product nameAnti-P protein antibody
DescriptionRabbit polyclonal to P protein
Tested applicationsSuitable for: WB, IHC-Pmore details
Species reactivityReacts with: Mouse, Human
Recombinant fragment within Human P protein (N terminal). The exact sequence is proprietary.
Database link: Q04671
- Mouse eye tissue lysate - total protein (ab4029) can be used as a positive control in WB. 293T, SGC-7901, U937, BT474 cell lysates; mouse testis, craniofacial and eye tissues lysates
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
Storage bufferpH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.87% Sodium chloride
PBS is without Mg2+ and Ca2+
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab196500 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/2000. Predicted molecular weight: 93 kDa.|
|IHC-P||1/50 - 1/200.|
FunctionCould be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color.
Involvement in diseaseDefects in OCA2 are the cause of albinism oculocutaneous type 2 (OCA2) [MIM:203200]. An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. Although affected infants may appear at birth to have complete absence of melanin pigment, most patients acquire small amounts of pigment with age. Visual anomalies include decreased acuity and nystagmus. The phenotype is highly variable. The hair of affected individuals may turn darker with age, and pigmented nevi or freckles may be seen. African and African American individuals may have yellow hair and blue-gray or hazel irides. One phenotypic variant, 'brown OCA,' has been described in African and African American populations and is characterized by light brown hair and skin color and gray to tan irides.
Sequence similaritiesBelongs to the CitM (TC 2.A.11) transporter family.
Cellular localizationMelanosome membrane.
- Information by UniProt
- BEY antibody
- BEY1 antibody
- BEY2 antibody
All lanes : Anti-P protein antibody (ab196500) at 1/500 dilution
Lane 1 : 293T cell lysate
Lane 2 : SGC-7901 cell lysate
Lane 3 : U937 cell lysate
Lane 4 : BT474 cell lysate
Lane 5 : Mouse testis tissue lysate
Lane 6 : Mouse craniofacial tissue lysate
Lane 7 : Mouse eye tissue lysate
Predicted band size: 93 kDa
ab196500 has not yet been referenced specifically in any publications.