Overview

  • Product name

    Anti-P protein antibody
  • Description

    Rabbit polyclonal to P protein
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Human
  • Immunogen

    Recombinant fragment within Human P protein (N terminal). The exact sequence is proprietary.
    Database link: Q04671

  • Positive control

    • Mouse eye tissue lysate - total protein (ab4029) can be used as a positive control in WB. 293T, SGC-7901, U937, BT474 cell lysates; mouse testis, craniofacial and eye tissues lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab196500 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 93 kDa.
IHC-P 1/50 - 1/200.

Target

  • Function

    Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color.
  • Involvement in disease

    Defects in OCA2 are the cause of albinism oculocutaneous type 2 (OCA2) [MIM:203200]. An autosomal recessive disorder in which the biosynthesis of melanin pigment is reduced in skin, hair, and eyes. Although affected infants may appear at birth to have complete absence of melanin pigment, most patients acquire small amounts of pigment with age. Visual anomalies include decreased acuity and nystagmus. The phenotype is highly variable. The hair of affected individuals may turn darker with age, and pigmented nevi or freckles may be seen. African and African American individuals may have yellow hair and blue-gray or hazel irides. One phenotypic variant, 'brown OCA,' has been described in African and African American populations and is characterized by light brown hair and skin color and gray to tan irides.
  • Sequence similarities

    Belongs to the CitM (TC 2.A.11) transporter family.
  • Cellular localization

    Melanosome membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • BEY antibody
    • BEY1 antibody
    • BEY2 antibody
    • BOCA antibody
    • D15S12 antibody
    • EYCL antibody
    • EYCL2 antibody
    • EYCL3 antibody
    • eye color 2 (central brown) antibody
    • eye color 3 (brown) antibody
    • hair color 3 (brown) antibody
    • HCL3 antibody
    • Melanocyte-specific transporter protein antibody
    • OCA2 antibody
    • oculocutaneous albinism II antibody
    • oculocutaneous albinism II (pink-eye dilution homolog, mouse) antibody
    • P antibody
    • P protein antibody
    • P_HUMAN antibody
    • PED antibody
    • Pink eyed dilution protein homolog antibody
    • Pink-eyed dilution protein homolog antibody
    • SHEP1 antibody
    • total brown iris pigmentation antibody
    see all

Images

  • All lanes : Anti-P protein antibody (ab196500) at 1/500 dilution

    Lane 1 : 293T cell lysate
    Lane 2 : SGC-7901 cell lysate
    Lane 3 : U937 cell lysate
    Lane 4 : BT474 cell lysate
    Lane 5 : Mouse testis tissue lysate
    Lane 6 : Mouse craniofacial tissue lysate
    Lane 7 : Mouse eye tissue lysate

    Predicted band size: 93 kDa

References

ab196500 has not yet been referenced specifically in any publications.

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