p-Xyleneselenocyanate (1,4-Phenylenebis(methylene)selenocyanate), chemopreventive agent (ab142600)

Overview

  • Product name

    p-Xyleneselenocyanate (1,4-Phenylenebis(methylene)selenocyanate), chemopreventive agent
  • Description

    Potent chemopreventive agent
  • Alternative names

    • 1,4-Phenylenebis(methylene)selenocyanate
  • Biological description

    Potent chemopreventive agent. Inhibits tumorigenesis and carcinogen-induced DNA methylation in vivo. Orally active.
  • Purity

    > 99%
  • CAS Number

    85539-83-9
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    [4-(Selenocyanatomethyl)phenyl]methyl selenocyanate
  • Molecular weight

    314.10
  • Molecular formula

    C10H8N2Se2
  • PubChem identifier

    5708
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=CC(=CC=C1C[Se]C#N)C[Se]C#N
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Emmert SW  et al. Induction of lung glutathione and glutamylcysteine ligase by 1,4-phenylenebis(methylene)selenocyanate and its glutathione conjugate: role of nuclear factor-erythroid 2-related factor 2. Free Radic Biol Med 52:2064-71 (2012). Read more (PubMed: 22542796) »
  • Guttenplan J  et al. Effects of 1,4-phenylenebis(methylene)selenocyanate on mutagenesis and p53 protein expression in the tongue of lacI rats treated with 4-nitroquinoline-N-oxide. Mutat Res 634:146-55 (2007). Read more (PubMed: 17720616) »
  • Das A  et al. Comparison of the chemopreventive efficacies of 1,4-phenylenebis(methylene)selenocyanate and selenium-enriched yeast on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone induced lung tumorigenesis in A/J mouse. Nutr Cancer 46:179-85 (2003). Read more (PubMed: 14690794) »
  • Tanaka T  et al. 1,4-phenylenebis(methylene)selenocyanate exerts exceptional chemopreventive activity in rat tongue carcinogenesis. Cancer Res 57:3644-8 (1997). Read more (PubMed: 9288763) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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