Overview

  • Product name

    Anti-p15 INK4b antibody - C-terminal
    See all p15 INK4b primary antibodies
  • Description

    Goat polyclonal to p15 INK4b - C-terminal
  • Host species

    Goat
  • Specificity

    This antibody is expected to recognize isoform 2 (NP_511042.1) only.
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to Human p15 INK4b aa 61-71 (C terminal) (Cysteine residue).
    Sequence:

    C-RQGARERGARP


    Database link: P42772-2

  • Positive control

    • WB: Human gastrointestinal cancer lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab223667 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 3 µg/ml. Detects a band of approximately 12, 14 kDa (predicted molecular weight: 8.1 kDa).

Target

  • Function

    Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.
  • Sequence similarities

    Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
    Contains 4 ANK repeats.
  • Information by UniProt
  • Database links

  • Alternative names

    • CDK inhibitory protein antibody
    • CDK4B Inhibitor antibody
    • Cdkn2b antibody
    • CDN2B_HUMAN antibody
    • Cyclin dependent kinase 4 inhibitor B antibody
    • Cyclin Dependent Kinase Inhibitor 2B antibody
    • Cyclin dependent kinase inhibitor 2B p15 inhibits CDK4 antibody
    • Cyclin dependent kinases 4 and 6 binding protein antibody
    • Cyclin-dependent kinase 4 inhibitor B antibody
    • INK4B antibody
    • MTS 2 antibody
    • MTS-2 antibody
    • MTS2 antibody
    • Multiple tumor suppressor 2 antibody
    • Multiple Tumor Supressor 2 antibody
    • OTTHUMP00000021154 antibody
    • OTTHUMP00000021155 antibody
    • p14 CDK inhibitor antibody
    • p14 INK4b antibody
    • p14-INK4b antibody
    • P15 antibody
    • p15 CDK inhibitor antibody
    • p15 inhibits CDK4 antibody
    • p15 INK4b antibody
    • p15-INK4b antibody
    • p15INK4B antibody
    • TP 15 antibody
    • TP15 antibody
    see all

Images

  • All lanes : Anti-p15 INK4b antibody - C-terminal (ab223667) at 1 µg/ml

    Lane 1 : Human gastrointestinal cancer lysate
    Lane 2 : Human gastrointestinal cancer lysate with Immunizing peptide

    Lysates/proteins at 35 µg per lane.

    Developed using the ECL technique.

    Predicted band size: 8.1 kDa
    Observed band size: 12,14 kDa
    why is the actual band size different from the predicted?



    Primary incubation was 1 hour

References

ab223667 has not yet been referenced specifically in any publications.

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