Anti-p15 INK4b antibody [DCS-114] (ab44891)
- Datasheet
- References (4)
- Protocols
Overview
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Product name
Anti-p15 INK4b antibody [DCS-114]
See all p15 INK4b primary antibodies -
Description
Mouse monoclonal [DCS-114] to p15 INK4b -
Host species
Mouse -
Tested applications
Suitable for: ICC/IF, IPmore details
Unsuitable for: WB -
Species reactivity
Reacts with: Human
Does not react with: Mouse, Rat -
Immunogen
Purified recombinant full length protein (Human)
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Positive control
- Ls174T cells
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.40
Preservative: 0.1% Sodium azide
Constituent: PBS -
Concentration information loading... -
Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
DCS-114 -
Isotype
IgG1 -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
Our Abpromise guarantee covers the use of ab44891 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| ICC/IF | ||
| IP |
Application notes
ICC/IF: Use at an assay dependent dilution.
IP (Native verified): 1/400 (Use Protein G. Co-precipitation of cdk4/cdk6)
Is unsuitable for WB.
Is unsuitable for Immunohistology.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
IP (Native verified): 1/400 (Use Protein G. Co-precipitation of cdk4/cdk6)
Is unsuitable for WB.
Is unsuitable for Immunohistology.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
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Function
Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest. -
Sequence similarities
Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
Contains 4 ANK repeats. - Information by UniProt
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Database links
- Entrez Gene: 1030 Human
- Omim: 600431 Human
- SwissProt: P42772 Human
- Unigene: 72901 Human
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Alternative names
- CDK inhibitory protein antibody
- CDK4B Inhibitor antibody
- Cdkn2b antibody
see all
References
This product has been referenced in:
- Gray-Bablin J et al. Lovastatin induction of cyclin-dependent kinase inhibitors in human breast cells occurs in a cell cycle-independent fashion. Cancer Res 57:604-9 (1997). Read more (PubMed: 9044834) »
- Naumann M et al. Frequent codeletion of p16/MTS1 and p15/MTS2 and genetic alterations in p16/MTS1 in pancreatic tumors. Gastroenterology 110:1215-24 (1996). Read more (PubMed: 8613012) »
