Anti-p15 INK4b antibody [DCS-114] (ab44891)
Key features and details
- Mouse monoclonal [DCS-114] to p15 INK4b
- Suitable for: ELISA, ICC, IP, ICC/IF, IHC
- Reacts with: Human
- Isotype: IgG1
Overview
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Product name
Anti-p15 INK4b antibody [DCS-114]
See all p15 INK4b primary antibodies -
Description
Mouse monoclonal [DCS-114] to p15 INK4b -
Host species
Mouse -
Tested applications
Suitable for: ELISA, ICC, IP, ICC/IF, IHCmore details
Unsuitable for: WB -
Species reactivity
Reacts with: Human
Does not react with: Mouse, Rat -
Immunogen
Recombinant full length protein corresponding to Human p15 INK4b.
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Positive control
- Ls174T cells
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.40
Preservative: 0.1% Sodium azide
Constituent: PBS -
Concentration information loading... -
Purity
Protein G purified -
Clonality
Monoclonal -
Clone number
DCS-114 -
Isotype
IgG1 -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab44891 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| ELISA |
Use at an assay dependent concentration.
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| ICC |
Use at an assay dependent concentration.
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| IF |
Use at an assay dependent concentration.
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| IP |
Use at an assay dependent concentration.
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| ICC/IF |
Use at an assay dependent concentration.
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| IHC |
Use at an assay dependent concentration.
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| Notes |
|---|
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ELISA
Use at an assay dependent concentration. |
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ICC
Use at an assay dependent concentration. |
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IF
Use at an assay dependent concentration. |
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IP
Use at an assay dependent concentration. |
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ICC/IF
Use at an assay dependent concentration. |
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IHC
Use at an assay dependent concentration. |
Target
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Function
Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest. -
Sequence similarities
Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.
Contains 4 ANK repeats. - Information by UniProt
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Database links
- Entrez Gene: 1030 Human
- Omim: 600431 Human
- SwissProt: P42772 Human
- Unigene: 72901 Human
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Alternative names
- CDK inhibitory protein antibody
- CDK4B Inhibitor antibody
- Cdkn2b antibody
see all
Protocols
Datasheets and documents
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SDS download
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Datasheet download
References (4)
ab44891 has been referenced in 4 publications.
- Gray-Bablin J et al. Lovastatin induction of cyclin-dependent kinase inhibitors in human breast cells occurs in a cell cycle-independent fashion. Cancer Res 57:604-9 (1997). PubMed: 9044834
- Naumann M et al. Frequent codeletion of p16/MTS1 and p15/MTS2 and genetic alterations in p16/MTS1 in pancreatic tumors. Gastroenterology 110:1215-24 (1996). PubMed: 8613012
- Saxena A et al. Abnormalities of p16, p15 and CDK4 genes in recurrent malignant astrocytomas. Oncogene 13:661-4 (1996). PubMed: 8760309
- Takeuchi S et al. Analysis of a family of cyclin-dependent kinase inhibitors: p15/MTS2/INK4B, p16/MTS1/INK4A, and p18 genes in acute lymphoblastic leukemia of childhood. Blood 86:755-60 (1995). PubMed: 7606004