Anti-P2Y12 antibody - N-terminal (ab140862)
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Overview
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Product name
Anti-P2Y12 antibody - N-terminal
See all P2Y12 primary antibodies -
Description
Rabbit polyclonal to P2Y12 - N-terminal -
Host species
Rabbit -
Specificity
BLAST analysis of the peptide immunogen showed no homology with other Human proteins. -
Tested applications
Suitable for: IHC-P, ICCmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Monkey, Gorilla, Common marmoset
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Immunogen
Synthetic peptide corresponding to Human P2Y12 (N terminal).
Database link: Q9H244 -
Positive control
- Human blood platelets; HEK293 human embryonic kidney cells transfected with P2RY12.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. -
Storage buffer
Preservative: 0.1% Sodium azide
Constituent: 99% PBS -
Concentration information loading... -
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
Our Abpromise guarantee covers the use of ab140862 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| IHC-P | Use a concentration of 32 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. | |
| ICC | Use at an assay dependent concentration. |
Target
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Function
Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelets aggregation. -
Tissue specificity
Highly expressed in the platelets, lower levels in the brain. Lowest levels in the lung, appendix, pituitary and adrenal gland. Expressed in the spinal cord and in the fetal brain. -
Involvement in disease
Defects in P2RY12 are the cause of P2RY12 deficiency (P2RY12D) [MIM:609821]. It is a condition characterized by severe impairment of platelet response to ADP and abnormal bleeding marked by excessive posttraumatic and postsurgical blood loss. -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 100396621 Common marmoset
- Entrez Gene: 101151637 Gorilla
- Entrez Gene: 64805 Human
- Omim: 600515 Human
- SwissProt: Q9H244 Human
- Unigene: 591281 Human
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Alternative names
- ADP glucose receptor antibody
- ADP-glucose receptor antibody
- ADPG R antibody
see all
Images
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-P2Y12 antibody - N-terminal (ab140862)Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human blood platelet tissue labelling P2Y12 with ab140862 at 32 µg/ml. -
Immunocytochemistry - Anti-P2Y12 antibody - N-terminal (ab140862)Immunocytochemical analysis of HEK293 Human embryonic kidney cells, transfected with P2RY12 labelling P2Y12 with ab140862.
References
ab140862 has not yet been referenced specifically in any publications.
