Key features and details
- Rabbit polyclonal to P2Y12 - N-terminal
- Suitable for: IHC-P, ICC
- Reacts with: Human
- Isotype: IgG
Product nameAnti-P2Y12 antibody - N-terminal
See all P2Y12 primary antibodies
DescriptionRabbit polyclonal to P2Y12 - N-terminal
SpecificityBLAST analysis of the peptide immunogen showed no homology with other Human proteins.
Tested applicationsSuitable for: IHC-P, ICCmore details
Species reactivityReacts with: Human
Predicted to work with: Monkey, Gorilla, Common marmoset
Synthetic peptide corresponding to Human P2Y12 (N terminal).
Database link: Q9H244
- Human blood platelets; HEK293 human embryonic kidney cells transfected with P2RY12.
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C.
Storage bufferPreservative: 0.1% Sodium azide
Constituent: 99% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab140862 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use a concentration of 32 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|
|ICC||Use at an assay dependent concentration.|
FunctionReceptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelets aggregation.
Tissue specificityHighly expressed in the platelets, lower levels in the brain. Lowest levels in the lung, appendix, pituitary and adrenal gland. Expressed in the spinal cord and in the fetal brain.
Involvement in diseaseDefects in P2RY12 are the cause of P2RY12 deficiency (P2RY12D) [MIM:609821]. It is a condition characterized by severe impairment of platelet response to ADP and abnormal bleeding marked by excessive posttraumatic and postsurgical blood loss.
Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
Cellular localizationCell membrane.
- Information by UniProt
- ADP glucose receptor antibody
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ab140862 has not yet been referenced specifically in any publications.