Key features and details
- Rabbit polyclonal to P2Y4 - Extracellular domain
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Product nameAnti-P2Y4 antibody - Extracellular domain
See all P2Y4 primary antibodies
DescriptionRabbit polyclonal to P2Y4 - Extracellular domain
SpecificityBLAST analysis of the peptide immunogen showed no homology with other Human proteins.
Tested applicationsSuitable for: IHC-Pmore details
Species reactivityReacts with: Human
Predicted to work with: Gorilla
Synthetic peptide, corresponding to 15 amino acids from the second extracellular domain of Human P2Y4 (NP_002556.1).
- Human spleen tissue.
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In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
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Storage instructionsShipped at 4°C.
Storage bufferPreservative: 0.1% Sodium azide
Constituent: 99% PBS
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab140857 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|IHC-P||Use a concentration of 6 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.|
FunctionReceptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP.
Sequence similaritiesBelongs to the G-protein coupled receptor 1 family.
modificationsPhosphorylation of Ser-333 and Ser-334 is a key step in agonist-dependent desensitization and loss of surface P2RY4. This phosphorylation does not involve PKC, nor other calcium activated kinases.
Cellular localizationCell membrane.
- Information by UniProt
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ab140857 has been referenced in 1 publication.
- Zaidman NA et al. Large-conductance Ca(2+) -activated K(+) channel activation by apical P2Y receptor agonists requires hydrocortisone in differentiated airway epithelium. J Physiol 595:4631-4645 (2017). Human . PubMed: 28481415