Overview

  • Product name

    Anti-P2Y4 antibody - Extracellular domain
    See all P2Y4 primary antibodies
  • Description

    Rabbit polyclonal to P2Y4 - Extracellular domain
  • Host species

    Rabbit
  • Specificity

    BLAST analysis of the peptide immunogen showed no homology with other Human proteins.
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Gorilla
  • Immunogen

    Synthetic peptide, corresponding to 15 amino acids from the second extracellular domain of Human P2Y4 (NP_002556.1).

  • Positive control

    • Human spleen tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab140857 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 6 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. Not activated by ATP or ADP.
  • Tissue specificity

    Pancreas.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family.
  • Post-translational
    modifications

    Phosphorylation of Ser-333 and Ser-334 is a key step in agonist-dependent desensitization and loss of surface P2RY4. This phosphorylation does not involve PKC, nor other calcium activated kinases.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • NRU antibody
    • Nucleotide receptor uridine antibody
    • P2P antibody
    • P2ry4 antibody
    • P2RY4_HUMAN antibody
    • P2Y purinoceptor 4 antibody
    • P2Y4 antibody
    • P2Y4R antibody
    • Pyrimidinergic receptor P2Y G protein coupled 4 antibody
    • UNR antibody
    • Uridine nucleotide receptor antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human spleen tissue labelling P2Y4 with ab140857 at 6 µg/ml.

References

This product has been referenced in:

  • Zaidman NA  et al. Large-conductance Ca(2+) -activated K(+) channel activation by apical P2Y receptor agonists requires hydrocortisone in differentiated airway epithelium. J Physiol 595:4631-4645 (2017). Human . Read more (PubMed: 28481415) »
See 1 Publication for this product

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