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Signal Transduction Protein Trafficking Golgi Proteins
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Anti-p40 - DeltaNp63 antibody (ab166857)

  • Datasheet
  • SDS
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p40 - DeltaNp63 antibody (ab166857)

    Key features and details

    • Rabbit polyclonal to p40 - DeltaNp63
    • Suitable for: IHC-P
    • Reacts with: Human
    • Isotype: IgG

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    Overview

    • Product name

      Anti-p40 - DeltaNp63 antibody
      See all p40 - DeltaNp63 primary antibodies
    • Description

      Rabbit polyclonal to p40 - DeltaNp63
    • Host species

      Rabbit
    • Specificity

      ab166857 recognizes deltaNp63- a p63 isoform
    • Tested applications

      Suitable for: IHC-Pmore details
    • Species reactivity

      Reacts with: Human
      Predicted to work with: Mouse, Rat, Cow
    • Immunogen

      Synthetic peptide corresponding to Human p40 - DeltaNp63 aa 5-17.
      Sequence:

      ENNAQTQFSEPQY


      Database link: Q9H3D4
      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
    • Positive control

      • Lung squamous cell carcinoma and Prostate tissues.
    • General notes

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
    • Storage buffer

      Preservative: 0.05% Sodium azide
      Constituents: 98% PBS, 1% BSA
    • Concentration information loading...
    • Purity

      Proprietary Purification
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Signal Transduction
      • Protein Trafficking
      • Golgi Proteins
      • Cell Biology
      • Other Antibodies
      • Other Antibodies
      • Metabolism
      • Types of disease
      • Cancer

    Associated products

    • Compatible Secondaries

      • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
      • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    • Isotype control

      • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab166857 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    IHC-P
    1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
    Notes
    IHC-P
    1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

    Target

    • Relevance

      Differentiating between lung adenocarcinoma and squamous cell carcinoma is an important distinction with therapeutic implications. Although the most frequently recommended squamous marker p63 is extremely sensitive, it suffers from low specificity due to its reactivity in a substantial proportion of lung adenocarcinomas and other tumor types, particularly lymphomas. p40 is a relatively unknown marker that recognizes ?Np63-a p63 isoform suggested to be highly specific for squamous/basal cells. p40 is equivalent to p63 in sensitivity for squamous cell carcinoma, but it is markedly superior to p63 in specificity, which eliminates a potential pitfall of misinterpreting a p63-positive adenocarcinoma or unsuspected lymphoma as squamous cell carcinoma. These findings strongly support the routine use of p40 in place of p63 for the diagnosis of pulmonary squamous cell carcinoma.
    • Database links

      • SwissProt: Q9H3D4 Human
      • Alternative names

        • 40 kDa Rab9 effector protein antibody
        • 8430412M01Rik antibody
        • 9530020d24rik antibody
        • AV073337 antibody
        • bA65N13.1 antibody
        • C87311 antibody
        • DKFZp686P1077 antibody
        • OTTHUMP00000022126 antibody
        • OTTMUSP00000012898 antibody
        • OTTMUSP00000012899 antibody
        • OTTMUSP00000041318 antibody
        • RAB9 effector p40 antibody
        • Rab9 effector protein with Kelch motifs antibody
        • RAB9p40 antibody
        • RABEK_HUMAN antibody
        • RABEPK antibody
        • RABEPK protein antibody
        • RGD1310612 antibody
        • RP11 65N13.1 antibody
        • RP23-446N16.2 antibody
        see all

      Images

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p40 - DeltaNp63 antibody (ab166857)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-p40 - DeltaNp63 antibody (ab166857)

        Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human Lung squamous Cell Ca, labeling p40 - DeltaNp63  using ab166857 at a 1/50 dilution.

      Protocols

      • Immunohistochemistry protocols

      Click here to view the general protocols

      Datasheets and documents

      • SDS download

      • Datasheet download

        Download

      References (2)

      Publishing research using ab166857? Please let us know so that we can cite the reference in this datasheet.

      ab166857 has been referenced in 2 publications.

      • Okada Y  et al. Shp2-mediated MAPK pathway regulates ?Np63 in epithelium to promote corneal innervation and homeostasis. Lab Invest 100:630-642 (2020). PubMed: 31653968
      • Zhao J  et al. CircRNA Expression Profile in Early-Stage Lung Adenocarcinoma Patients. Cell Physiol Biochem 44:2138-2146 (2017). PubMed: 29241190

      Customer reviews and Q&As

      Show All Reviews Q&A
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