Product nameAnti-p40 - DeltaNp63 antibody
See all p40 - DeltaNp63 primary antibodies
DescriptionRabbit polyclonal to p40 - DeltaNp63
Specificityab167612 detects a short form of Tumor protein 63 (UniProt ID Q9H3D4) - p40 - DeltaNp63.
Tested applicationsSuitable for: WB, IHC-Pmore details
Species reactivityReacts with: Human
- IHC-P: Human lung squamous cell carcinoma tissue.
Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term.
Storage bufferPreservative: 0.09% Sodium azide
Buffer with protein carrier.
Concentration information loading...
Our Abpromise guarantee covers the use of ab167612 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||Use at an assay dependent concentration. PubMed: 29637001|
|IHC-P||1/100 - 1/200. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.|
RelevanceDifferentiating between lung adenocarcinoma and squamous cell carcinoma is an important distinction with therapeutic implications. Although the most frequently recommended squamous marker p63 is extremely sensitive, it suffers from low specificity due to its reactivity in a substantial proportion of lung adenocarcinomas and other tumor types, particularly lymphomas. p40 is a relatively unknown marker that recognizes ?Np63-a p63 isoform suggested to be highly specific for squamous/basal cells. p40 is equivalent to p63 in sensitivity for squamous cell carcinoma, but it is markedly superior to p63 in specificity, which eliminates a potential pitfall of misinterpreting a p63-positive adenocarcinoma or unsuspected lymphoma as squamous cell carcinoma. These findings strongly support the routine use of p40 in place of p63 for the diagnosis of pulmonary squamous cell carcinoma.
- SwissProt: Q9H3D4 Human
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This product has been referenced in:
- Gu H et al. Highly expressed histone deacetylase 5 promotes the growth of hepatocellular carcinoma cells by inhibiting the TAp63-maspin pathway. Am J Cancer Res 8:462-475 (2018). WB ; Human . Read more (PubMed: 29637001) »
- Fu Y et al. Ductal activation of oncogenic KRAS alone induces sarcomatoid phenotype. Sci Rep 5:13347 (2015). Read more (PubMed: 26289340) »