Overview

  • Product name

  • Description

    Rabbit polyclonal to p53R2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-P, WBmore details
  • Species reactivity

    Reacts with: Mouse, Human
    Predicted to work with: Rat
  • Immunogen

    Recombinant fragment within Human p53R2 (internal sequence). The exact sequence is proprietary.
    Database link: Q7LG56

  • Positive control

    • WB: IMR32 whole cell lysate; Mouse brain tissue lysate. IHC-P: Mouse lung tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab227291 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/1000.
WB 1/500 - 1/3000. Predicted molecular weight: 40 kDa.

Target

  • Function

    Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.
  • Tissue specificity

    Widely expressed at a high level in skeletal muscle and at a weak level in thymus. Expressed in epithelial dysplasias and squamous cell carcinoma.
  • Pathway

    Genetic information processing; DNA replication.
  • Involvement in disease

    Defects in RRM2B are the cause of mitochondrial DNA depletion syndrome type 8A (MTDPS8A) [MIM:612075]. A disorder due to mitochondrial dysfunction characterized by various combinations of neonatal hypotonia, neurological deterioration, respiratory distress, lactic acidosis, and renal tubulopathy.
    Defects in RRM2B are the cause of mitochondrial DNA depletion syndrome type 8B (MTDPS8B) [MIM:612075]. A disease due to mitochondrial dysfunction and characterized by ophthalmoplegia, ptosis, gastrointestinal dysmotility, cachexia, peripheral neuropathy.
    Defects in RRM2B are the cause of progressive external ophthalmoplegia with mitochondrial DNA deletions autosomal dominant type 5 (PEOA5) [MIM:613077]. A disorder characterized by progressive weakness of ocular muscles and levator muscle of the upper eyelid. In a minority of cases, it is associated with skeletal myopathy, which predominantly involves axial or proximal muscles and which causes abnormal fatigability and even permanent muscle weakness. Ragged-red fibers and atrophy are found on muscle biopsy. A large proportion of chronic ophthalmoplegias are associated with other symptoms, leading to a multisystemic pattern of this disease. Additional symptoms are variable, and may include cataracts, hearing loss, sensory axonal neuropathy, ataxia, depression, hypogonadism, and parkinsonism.
  • Sequence similarities

    Belongs to the ribonucleoside diphosphate reductase small chain family.
  • Cellular localization

    Cytoplasm. Nucleus. Translocates from cytoplasm to nucleus in response to DNA damage.
  • Information by UniProt
  • Database links

  • Alternative names

    • DKFZp686M05248 antibody
    • MGC102856 antibody
    • MGC42116 antibody
    • MTDPS8A antibody
    • MTDPS8B antibody
    • p53 inducible ribonucleotide reductase small subunit 2 homolog antibody
    • p53 inducible ribonucleotide reductase small subunit 2 like protein antibody
    • P53 inducible ribonucleotide reductase small subunit 2 short form beta antibody
    • p53 R2 antibody
    • p53-inducible ribonucleotide reductase small subunit 2-like protein antibody
    • p53R2 antibody
    • Ribonucleoside diphosphate reductase M2 subunit B antibody
    • Ribonucleoside-diphosphate reductase subunit M2 B antibody
    • Ribonucleotide reductase M2 B (TP53 inducible) antibody
    • Ribonucleotide reductase M2 B antibody
    • Ribonucleotide reductase small subunit like 2 p53 inducible antibody
    • RIR2B_HUMAN antibody
    • RRM 2B antibody
    • RRM2B antibody
    • TP53 inducible ribonucleotide reductase M2 B antibody
    • TP53-inducible ribonucleotide reductase M2 B antibody
    see all

Images

  • Anti-p53R2 antibody (ab227291) at 1/1000 dilution + IMR32 whole cell lysate at 30 µg

    Predicted band size: 40 kDa



    10% SDS-PAGE gel.

  • Anti-p53R2 antibody (ab227291) at 1/1000 dilution + Mouse brain tissue lysate at 50 µg

    Predicted band size: 40 kDa



    10% SDS-PAGE gel.

  • Paraffin-embedded mouse lung tissue stained for p53R2 using ab227291 at 1/500 dilution in immunohistochemical analysis.

References

ab227291 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab227291.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up