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Epigenetics and Nuclear Signaling DNA / RNA DNA Damage & Repair DNA Damage Response p53
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Anti-p53R2 antibody - C-terminal (ab191055)

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Western blot - Anti-p53R2 antibody - C-terminal (ab191055)

    Key features and details

    • Rabbit polyclonal to p53R2 - C-terminal
    • Suitable for: WB
    • Reacts with: Rat, Human
    • Isotype: IgG

    You may also be interested in

    Protein
    Product image
    Recombinant Human p53R2 protein (ab153320)
    Secondary
    Product image
    Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

    View more associated products

    Overview

    • Product name

      Anti-p53R2 antibody - C-terminal
      See all p53R2 primary antibodies
    • Description

      Rabbit polyclonal to p53R2 - C-terminal
    • Host species

      Rabbit
    • Specificity

      No cross reactivity with other proteins.
    • Tested applications

      Suitable for: WBmore details
    • Species reactivity

      Reacts with: Rat, Human
      Predicted to work with: Mouse, Saccharomyces cerevisiae, Caenorhabditis elegans, Cynomolgus monkey, Orangutan
    • Immunogen

      Synthetic peptide corresponding to Human p53R2 aa 318-332 (C terminal).
      Sequence:

      EGKTNFFEKRVSEYQ


      Database link: Q7LG56
      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
    • Positive control

      • Rat thymus tissue lysates: MCF7, A431 and HeLa cell lysates.
    • General notes

      Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

      Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

      We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

      In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

      We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

      Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

      Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
    • Storage buffer

      Preservatives: 0.025% Thimerosal (merthiolate), 0.025% Sodium azide
      Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Dibasic monohydrogen sodium phosphate
    • Concentration information loading...
    • Purity

      Immunogen affinity purified
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Epigenetics and Nuclear Signaling
      • DNA / RNA
      • DNA Damage & Repair
      • DNA Damage Response
      • p53
      • Cancer
      • Oncoproteins/suppressors
      • Tumor suppressors
      • p53 pathway
      • Metabolism
      • Pathways and Processes
      • Metabolic signaling pathways
      • Nucleotide metabolism

    Associated products

    • Compatible Secondaries

      • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
      • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    • Isotype control

      • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
    • Positive Controls

      • HeLa whole cell lysate (ab150035)
      • MCF7 whole cell lysate (ab29537)
      • HeLa whole cell lysate (ab29545)
      • A431 whole cell lysate (ab30132)
      • A431 whole cell lysate (ab7909)
    • Recombinant Protein

      • Recombinant Human p53R2 protein (ab153320)

    Applications

    Our Abpromise guarantee covers the use of ab191055 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Application Abreviews Notes
    WB Use a concentration of 0.1 - 0.5 µg/ml. Predicted molecular weight: 41 kDa.

    Target

    • Function

      Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.
    • Tissue specificity

      Widely expressed at a high level in skeletal muscle and at a weak level in thymus. Expressed in epithelial dysplasias and squamous cell carcinoma.
    • Pathway

      Genetic information processing; DNA replication.
    • Involvement in disease

      Defects in RRM2B are the cause of mitochondrial DNA depletion syndrome type 8A (MTDPS8A) [MIM:612075]. A disorder due to mitochondrial dysfunction characterized by various combinations of neonatal hypotonia, neurological deterioration, respiratory distress, lactic acidosis, and renal tubulopathy.
      Defects in RRM2B are the cause of mitochondrial DNA depletion syndrome type 8B (MTDPS8B) [MIM:612075]. A disease due to mitochondrial dysfunction and characterized by ophthalmoplegia, ptosis, gastrointestinal dysmotility, cachexia, peripheral neuropathy.
      Defects in RRM2B are the cause of progressive external ophthalmoplegia with mitochondrial DNA deletions autosomal dominant type 5 (PEOA5) [MIM:613077]. A disorder characterized by progressive weakness of ocular muscles and levator muscle of the upper eyelid. In a minority of cases, it is associated with skeletal myopathy, which predominantly involves axial or proximal muscles and which causes abnormal fatigability and even permanent muscle weakness. Ragged-red fibers and atrophy are found on muscle biopsy. A large proportion of chronic ophthalmoplegias are associated with other symptoms, leading to a multisystemic pattern of this disease. Additional symptoms are variable, and may include cataracts, hearing loss, sensory axonal neuropathy, ataxia, depression, hypogonadism, and parkinsonism.
    • Sequence similarities

      Belongs to the ribonucleoside diphosphate reductase small chain family.
    • Cellular localization

      Cytoplasm. Nucleus. Translocates from cytoplasm to nucleus in response to DNA damage.
    • Target information above from: UniProt accession Q7LG56 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 50484 Human
      • Entrez Gene: 382985 Mouse
      • Entrez Gene: 299976 Rat
      • Entrez Gene: 853427 Saccharomyces cerevisiae
      • Omim: 604712 Human
      • SwissProt: P42170 Caenorhabditis elegans
      • SwissProt: Q4R741 Cynomolgus monkey
      • SwissProt: Q7LG56 Human
      • SwissProt: Q6PEE3 Mouse
      • SwissProt: Q5R9G0 Orangutan
      • SwissProt: P09938 Saccharomyces cerevisiae
      • Unigene: 512592 Human
      • Unigene: 24738 Mouse
      see all
    • Alternative names

      • DKFZp686M05248 antibody
      • MGC102856 antibody
      • MGC42116 antibody
      • MTDPS8A antibody
      • MTDPS8B antibody
      • p53 inducible ribonucleotide reductase small subunit 2 homolog antibody
      • p53 inducible ribonucleotide reductase small subunit 2 like protein antibody
      • P53 inducible ribonucleotide reductase small subunit 2 short form beta antibody
      • p53 R2 antibody
      • p53-inducible ribonucleotide reductase small subunit 2-like protein antibody
      • p53R2 antibody
      • Ribonucleoside diphosphate reductase M2 subunit B antibody
      • Ribonucleoside-diphosphate reductase subunit M2 B antibody
      • Ribonucleotide reductase M2 B (TP53 inducible) antibody
      • Ribonucleotide reductase M2 B antibody
      • Ribonucleotide reductase small subunit like 2 p53 inducible antibody
      • RIR2B_HUMAN antibody
      • RRM 2B antibody
      • RRM2B antibody
      • TP53 inducible ribonucleotide reductase M2 B antibody
      • TP53-inducible ribonucleotide reductase M2 B antibody
      see all

    Images

    • Western blot - Anti-p53R2 antibody - C-terminal (ab191055)
      Western blot - Anti-p53R2 antibody - C-terminal (ab191055)
      All lanes : Anti-p53R2 antibody - C-terminal (ab191055) at 0.5 µg/ml

      Lane 1 : Rat thymus tissue lysate
      Lane 2 : MCF7 cell lysate
      Lane 3 : A431 cell lysate
      Lane 4 : HeLa cell lysate

      Predicted band size: 41 kDa

    Protocols

    • Western blot protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
    • SDS
  • References (0)

    Publishing research using ab191055? Please let us know so that we can cite the reference in this datasheet.

    ab191055 has not yet been referenced specifically in any publications.

    Customer reviews and Q&As

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