Overview

  • Product name

    Anti-p57 Kip2 antibody [SP118]
    See all p57 Kip2 primary antibodies
  • Description

    Rabbit monoclonal [SP118] to p57 Kip2
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide within Human p57 Kip2 aa 50-150 (internal sequence). The exact sequence is proprietary.
    Database link: P49918

  • Positive control

    • IHC-P: Human placenta, complete hydatidiform mole, and partial hydatidiform mole tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab231439 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100.

Boil tissue section in EDTA buffer for 10 minutes followed by cooling at room temperature for 20 minutes.

Incubate with primary antibody for 10 minutes at room temperature.

 

Target

  • Function

    Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.
  • Tissue specificity

    Expressed in the heart, brain, lung, skeletal muscle, kidney, pancreas and testis. High levels are seen in the placenta while low levels are seen in the liver.
  • Involvement in disease

    Defects in CDKN1C are a cause of Beckwith-Wiedemann syndrome (BWS) [MIM:130650]. BWS is a genetically heterogeneous disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth, and macroglossia. Additional less frequent complications include specific developmental defects and a predisposition to embryonal tumors.
    Note=Defects in CDKN1C are involved in tumor formation.
  • Sequence similarities

    Belongs to the CDI family.
  • Cellular localization

    Nucleus.
  • Information by UniProt
  • Database links

  • Alternative names

    • Beckwith Wiedemann syndrome antibody
    • BWCR antibody
    • BWS antibody
    • CDKI antibody
    • CDKN 1C antibody
    • CDKN1C antibody
    • CDN1C_HUMAN antibody
    • Cyclin dependent kinase inhibitor 1C antibody
    • Cyclin dependent kinase inhibitor p57 antibody
    • Cyclin-dependent kinase inhibitor 1C antibody
    • Cyclin-dependent kinase inhibitor p57 antibody
    • KIP 2 antibody
    • KIP2 antibody
    • p57 antibody
    • p57 Kip 2 antibody
    • p57KIP2 antibody
    • WBS antibody
    see all

Images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of Human placenta tissue sections labeling p57 Kip2 with ab231439 at 1/100 dilution (1.04 µg/ml). Heat mediated antigen retrieval was performed Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0, epitope retrieval solution 2) for 30 mins. Rabbit specific IHC polymer detection kit HRP/DAB (ab209101) was used as the secondary antibody. Negative control: PBS instead of the primary antibody. Hematoxylin was used as a counterstain.
  • Formalin-fixed, paraffin-embedded placenta tissue  stained for p57 Kip2 using ab231439 at 1/100 dilution in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded placenta tissue  stained for p57 Kip2 using ab231439 at 1/100 dilution in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded complete hydatidiform mole tissue stained for p57 Kip2 using ab231439 at 1/100 dilution in immunohistochemical analysis.

  • Formalin-fixed, paraffin-embedded partial hydatidiform mole tissue stained for p57 Kip2 using ab231439 at 1/100 dilution in immunohistochemical analysis.

References

ab231439 has not yet been referenced specifically in any publications.

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