Overview

  • Product name

  • Description

    Rabbit polyclonal to p60 katanin
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Chicken, Cow, Xenopus laevis, Zebrafish
  • Immunogen

    Recombinant fragment within Human p60 katanin (internal sequence). The exact sequence is proprietary.
    Database link: O75449

  • Positive control

    • WB: MCF7 whole cell lysate.
  • General notes

    Previously labelled as KATNA1.

Properties

Applications

Our Abpromise guarantee covers the use of ab228908 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000.

Target

  • Function

    Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays, such as during disassembly of interphase microtubules at the G2-M transition. May also be required for microtubule release from the centrosome after nucleation. In mitotic spindles this could allow depolymerization of the microtubule end proximal to the centrosome, and subsequent poleward microtubule flux. In neurons, microtubule release within the cell body may allow their subsequent transport into neuronal processes by microtubule dependent motor proteins. This transport is required for axonal growth.
  • Sequence similarities

    Belongs to the AAA ATPase family.
  • Domain

    The N-terminus is sufficient for interaction with microtubules, although high affinity binding requires an intact C-terminal domain and ATP, which promotes oligomerization.
  • Cellular localization

    Cytoplasm. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle pole. Predominantly cytoplasmic. Also localized to the interphase centrosome. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1.
  • Information by UniProt
  • Database links

  • Alternative names

    • Katanin p60 ATPase containing subunit A1 antibody
    • Katanin p60 ATPase-containing subunit A1 antibody
    • Katanin p60 subunit A1 antibody
    • KATNA1 antibody
    • KTNA1_HUMAN antibody
    • OTTHUMP00000017392 antibody
    • OTTHUMP00000042860 antibody
    • p60 katanin antibody
    see all

Images

  • Anti-p60 katanin antibody (ab228908) at 1/3000 dilution + MCF7 (human breast adenocarcinoma cell line) whole cell lysate at 30 µg

    Developed using the ECL technique.


    10% SDS-PAGE gel.

References

ab228908 has not yet been referenced specifically in any publications.

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