Overview

  • Product name
    PAC-1, caspase-3 activator
  • Description
    Potent caspase-3 activator
  • Biological description
    Potent caspase-3 activator (IC50 = 220 nM). Also activates caspase-7 (IC50 = 4.5 μM). Proapoptotic in vitro. Anticancer activity in vivo. Orally active.
  • Purity
    > 95%
  • CAS Number
    315183-21-2
  • Chemical structure
    Chemical Structure

Properties

  • Chemical name
    2-(4-Benzylpiperazin-1-yl)-N'-[(Z)-(6-oxo-5-prop-2-enylcyclohexa-2,4-dien-1-ylidene)methyl]acetohydrazide
  • Molecular weight
    392.49
  • Molecular formula
    C23H28N4O2
  • PubChem identifier
    6851947
  • Storage instructions
    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in water to 5 mM and in DMSO to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    C=CCC1=CC=CC(=CNNC(=O)CN2CCN(CC2)CC3=CC=CC=C3)C1=O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Seervi M  et al. Essential requirement of cytochrome c release for caspase activation by procaspase-activating compound defined by cellular models. Cell Death Dis 2:e207 (2011). Read more (PubMed: 21900958) »
  • Peterson QP  et al. Procaspase-3 activation as an anti-cancer strategy: structure-activity relationship of procaspase-activating compound 1 (PAC-1) and its cellular co-localization with caspase-3. J Med Chem 52:5721-31 (2009). Read more (PubMed: 19708658) »
  • Putt KS  et al. Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat Chem Biol 2:543-50 (2006). Read more (PubMed: 16936720) »
See 1 Publication for this product

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