Key features and details
- Potent caspase-3 activator
- CAS Number: 315183-21-2
- Purity: > 95%
- Soluble in water to 5 mM and in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Product namePAC-1, caspase-3 activator
DescriptionPotent caspase-3 activator
Biological descriptionPotent caspase-3 activator (IC50 = 220 nM). Also activates caspase-7 (IC50 = 4.5 μM). Proapoptotic in vitro. Anticancer activity in vivo. Orally active.
Storage instructionsStore at +4°C. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 5 mM and in DMSO to 25 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab142074 has been referenced in 1 publication.
- Dick SA et al. Caspase 3 cleavage of Pax7 inhibits self-renewal of satellite cells. Proc Natl Acad Sci U S A 112:E5246-52 (2015). PubMed: 26372956