Overview

  • Product name

    PACAP (6-27) (human, ovine, rat), receptor antagonist
  • Description

    Potent, competitive PACAP receptor antagonist. Inhibits stimulation of AC.
  • Biological description

    Potent, competitive PACAP receptor antagonist (Kd = 1 μM). Inhibits stimulation of adenylyl cyclase. Attenuates catecholamine response to exogenous VIP in vivo. Active in vitro and in vivo.
  • Purity

    > 95%
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Gaspo R  et al. Canine adrenal catecholamine response to VIP is blocked by PACAP-(6-27) in vivo. Am J Physiol 272:R1606-12 (1997). Read more (PubMed: 9176354) »
  • Olianas MC  et al. Presence of pituitary adenylate cyclase-activating polypeptide receptors in Y-79 human retinoblastoma cells. J Neurochem 67:1293-300 (1996). Read more (PubMed: 8752138) »
  • Hou X  et al. Structural requirements for the occupancy of rat brain PACAP receptors and adenylate cyclase activation. Neuropharmacology 33:1189-95 (1994). Read more (PubMed: 7862254) »

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