• Product name
    Anti-PACAP antibody [EPR11543(B)]
    See all PACAP primary antibodies
  • Description
    Rabbit monoclonal [EPR11543(B)] to PACAP
  • Host species
  • Tested applications
    Suitable for: WB, IPmore details
    Unsuitable for: Flow Cyt,ICC or IHC
  • Species reactivity
    Reacts with: Human
    Does not react with: Mouse, Rat
  • Immunogen

    Synthetic peptide within Human PACAP (Cysteine residue). The exact sequence is proprietary.
    Database link: Q8WU39

  • Positive control
    • Daudi, Ramos and Raji cell lysates.
  • General notes



     This product was previously labelled as Proapoptotic Caspase Adaptor Protein


    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.



Our Abpromise guarantee covers the use of ab170891 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/10000 - 1/50000. Predicted molecular weight: 21 kDa.
IP 1/10 - 1/100.
  • Application notes
    Is unsuitable for Flow Cyt,ICC or IHC.
  • Target

    • Function
      Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation.
      Acts as a hormone-regulated adipokine/proinflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance.
    • Tissue specificity
      Widely expressed with highest levels in adult brain, small intestine and lymphoid tissues such as thymus and spleen. Expression is frequently lower in intestinal-type gastric cancer. In obese patients, more abundant in omental than in subcutaneous fat.
    • Sequence similarities
      Belongs to the MZB1 family.
    • Post-translational
      Forms an interchain disulfide bond with IgM monomers.
    • Cellular localization
      Endoplasmic reticulum lumen. Secreted and Cytoplasm. Diffuse granular localization in the cytoplasm surrounding the nucleus (PubMed:11350957).
    • Information by UniProt
    • Database links
    • Alternative names
      • MZB1 antibody
      • Caspase 2 binding protein antibody
      • FLJ32987 antibody
      • HSPC190 antibody
      • Marginal zone B and B1 cell specific protein antibody
      • Marginal zone B- and B1-cell-specific protein antibody
      • MEDA 7 antibody
      • MEDA-7 antibody
      • Mesenteric estrogen dependent adipose 7 antibody
      • Mesenteric estrogen-dependent adipose 7 antibody
      • Mesenteric oestrogen dependent adipose gene 7 antibody
      • MGC29506 antibody
      • Mzb1 antibody
      • MZB1_HUMAN antibody
      • PACAP antibody
      • pERp1 antibody
      • Plasma cell-induced ER protein 1 antibody
      • Plasma cell-induced resident endoplasmic reticulum protein antibody
      • Plasma cell-induced resident ER protein antibody
      • Proapoptotic caspase adapter protein antibody
      see all


    • Western blot analysis on immunoprecipitation pellet from (1) Raji cell lysate or (2) 1X PBS (negative control) immunoprecipitated using ab170891 at 1/10 dilution. Detection utilized HRP-conjugated anti-rabbit IgG which preferentially detects the non-reduced form of rabbit IgG.

    • All lanes : Anti-PACAP antibody [EPR11543(B)] (ab170891) at 1/10000 dilution

      Lane 1 : Daudi cell lysates
      Lane 2 : Ramos cell lysates
      Lane 3 : Raji cell lysates

      Lysates/proteins at 10 µg per lane.

      All lanes : Goat anti-rabbit HRP at 1/2000 dilution

      Predicted band size: 21 kDa


    ab170891 has not yet been referenced specifically in any publications.

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