Overview

  • Product name

    PACAP(6-38) (human, ovine, rat), receptor antagonist
  • Description

    Potent, competitive PACAP receptor antagonist
  • Biological description

    Potent, competitive pituitary adenylate cyclase-activating polypeptide (PACAP) receptor antagonist (IC50 = 750 nM) (Ki = 1.5 nM). Hypothalamic peptide. Anti-cancer agent. Active in vitro and in vivo.
  • Purity

    > 95%
  • CAS Number

    137061-48-4
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Leyton J  et al. PACAP(6-38) is a PACAP receptor antagonist for breast cancer cells. Breast Cancer Res Treat 56:177-86 (1999). Read more (PubMed: 10573110) »
  • Arbogast LA & Voogt JL Pituitary adenylate cyclase-activating polypeptide (PACAP) increases prolactin release and tuberoinfundibular dopaminergic neuronal activity. Brain Res 655:17-24 (1994). Read more (PubMed: 7812770) »
  • Robberecht P  et al. Structural requirements for the occupancy of pituitary adenylate-cyclase-activating-peptide (PACAP) receptors and adenylate cyclase activation in human neuroblastoma NB-OK-1 cell membranes. Discovery of PACAP(6-38) as a potent antagonist. Eur J Biochem 207:239-46 (1992). Read more (PubMed: 1321043) »

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