For the best experience on the Abcam website please upgrade to a modern browser such as Google Chrome

Hello. We're improving abcam.com and we'd welcome your feedback.

Hello. We're improving abcam.com and we'd welcome your feedback.

Infomation icon

We haven't added this to the BETA yet

New BETA website

New BETA website

Hello. We're improving abcam.com and we'd welcome your feedback.

Take a look at our BETA site and see what we’ve done so far.

Switch on our new BETA site

Now available

Search and browse selected products

  • A selection of primary antibodies

Purchase these through your usual distributor

In the coming months

  • Additional product types
  • Supporting content
  • Sign in to your account
  • Purchase online
United States
Your country/region is currently set to:

If incorrect, please enter your country/region into the box below, to view site information related to your country/region.

Call (888) 77-ABCAM (22226) or contact us
Need help? Contact us

  • My account
  • Sign out
Sign in or Register with us

Welcome

Sign in or

Don't have an account?

Register with us
My basket
Quick order
Abcam homepage

  • Research Products
    By product type
    Primary antibodies
    Secondary antibodies
    ELISA and Matched Antibody Pair Kits
    Cell and tissue imaging tools
    Cellular and biochemical assays
    Proteins and Peptides
    By product type
    Proteomics tools
    Agonists, activators, antagonists and inhibitors
    Cell lines and Lysates
    Multiplex miRNA assays
    Multiplex Assays
    By research area
    Cancer
    Cardiovascular
    Cell Biology
    Epigenetics
    Metabolism
    Developmental Biology
    By research area
    Immunology
    Microbiology
    Neuroscience
    Signal Transduction
    Stem Cells
  • Customized Products & Partnerships
    Customized Products & Partnerships

    Customized products and commercial partnerships to accelerate your diagnostic and therapeutic programs.

    Customized products

    Partner with us

  • Support
    Support hub

    Access advice and support for any research roadblock

    View support hub

    Protocols

    Your experiments laid out step by step

    View protocols

  • Events
    • Conference calendar
    • Cancer
    • Cardiovascular
    • Epigenetics & Nuclear signaling
    • Immunology
    • Neuroscience
    • Stem cells
    • Tradeshows
    • Scientific webinars
    Keep up to date with the latest events

    Full event breakdown with abstracts, speakers, registration and more

    View global event calendar

  • Pathways
    Cell signalling pathways

    View all pathways

    View all interactive pathways

  1. Link

    paclitaxel-anticancer-agent-ab120143.pdf

  1. Send me a copy of this email
    I agree to the terms and conditions.
Biochemicals Chemical Type Biochemicals
Share by email

Paclitaxel, Anticancer agent (ab120143)

  • Datasheet
  • SDS
  • COA
Reviews (1) Submit a question References (10)

Product price, shipping and contact information

Currently unavailable

Sorry, we can't display this right now.

Please contact us to place your order, or try again later.

 

Loading size & price…

 

Shipping and order information

Shipping info

Promotion Information

Abpromise

Guaranteed product quality, expert customer support.

Find out more.

Chemical Structure - Paclitaxel, Anticancer agent (ab120143)
  • Functional Studies - Paclitaxel, Anticancer agent (ab120143)

Key features and details

  • Anticancer agent
  • CAS Number: 33069-62-4
  • Soluble in DMSO to 100 mM and in ethanol to 25 mM
  • Form / State: Solid
  • Source: Synthetic

Overview

  • Product name

    Paclitaxel, Anticancer agent
  • Description

    Anticancer agent
  • Alternative names

    • Taxol
  • CAS Number

    33069-62-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5ß,20-Epoxy-1,2a,4,7ß,10ß,13a-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
  • Molecular weight

    853.91
  • Molecular formula

    C47H51NO14
  • PubChem identifier

    36314
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Refer to SDS for further information.

    Note: Some researchers have found solubility issues in PBS. The recommended procedure (from researcher feedback) for successful solubilisation is as follows: Solubilise 10 mg of ab120143 in 1.25 mL ethanol absolute, mix well, add 1.25mL Cremophor, homogenise. Store at -20°C and after 24 h, defreeze quickly and solubilise in PBS, no crystallisation observed. Please note, Abcam has not yet tested this method.

     

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    O=C(N[C@@H](c1ccccc1)[C@@H](O)C(=O)O[C@H]5C[C@@]6(O)[C@@H](OC(=O)c2ccccc2)[C@H]3[C@@](C)([C@@H](O)C[C@H]4OC[C@@]34OC(C)=O)C(=O)[C@H](OC(C)=O)C(=C5C)C6(C)C)c7ccccc7
  • Source

    Synthetic

  • Research areas

    • Biochemicals
    • Chemical Type
    • Biochemicals
    • Biochemicals
    • Pharmacology
    • Signaling
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Research Area
    • Heart disease
    • Signaling
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Research Area
    • Pain & inflammation
    • Signaling
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Research Area
    • Alzheimer's Disease
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Research Area
    • Alzheimer's Disease
    • Signaling
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Research Area
    • Cancer
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Research Area
    • Diabetes
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Research Area
    • Diabetes
    • Signaling
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Research Area
    • Heart disease
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Research Area
    • Hypertension
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Research Area
    • Hypertension
    • Signaling
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Research Area
    • Obesity
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Research Area
    • Obesity
    • Signaling
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Research Area
    • Pain & inflammation
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Research Area
    • Respiratory disease
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Research Area
    • Respiratory disease
    • Signaling
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Research Area
    • Stroke
    • Apoptosis & cell cycle
    • Other
    • Biochemicals
    • Research Area
    • Stroke
    • Signaling
    • Apoptosis & cell cycle
    • Other

Images

  • Chemical Structure - Paclitaxel, Anticancer agent (ab120143)
    Chemical Structure - Paclitaxel, Anticancer agent (ab120143)
    2D chemical structure image of ab120143, Paclitaxel, Anticancer agent
  • Functional Studies - Paclitaxel, Anticancer agent (ab120143)
    Functional Studies - Paclitaxel, Anticancer agent (ab120143)Dong et al PLoS One. 2013; 8(12): e83519. Reproduced under the Creative Commons license http://creativecommons.org/licenses/by/4.0/

    E2 inhibits Paclitaxel induced androgen-independent prostate cancer cell death.

    (A-D) 100 nM of E2 was added to the media of (A and B) LNCaP and (C and D) PC3 cells for 96h, followed by addition of Paclitaxel at the indicated concentrations for 24h. The cells were stained with Hoechst 33258 (5 µg/ml) to visualize nuclei and propidium iodide (PI) (0.2 µg/ml) to detect membrane damage (B and D). Cell death was quantified by scoring the number of PI positive cells relative to the total number cell nuclei in the same visual field (A and C). The values represent the mean ± S.E. of at least three independent experiments. * denotes p<0.05, ** denotes p<0.01, and *** denotes p<0.001.

    E2 = 17-β-estradiol

    (From Figure 1 of Dong et al).

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

  • SDS download

  • Datasheet download

    Download
  • COA

References (10)

Publishing research using ab120143? Please let us know so that we can cite the reference in this datasheet.

ab120143 has been referenced in 10 publications.

  • Samanta J  et al. Oleic Acid Protects from Arsenic-Induced Cardiac Hypertrophy via AMPK/FoxO/NFATc3 Pathway. Cardiovasc Toxicol 20:261-280 (2020). PubMed: 31571030
  • Rose JC  et al. Biofunctionalized aligned microgels provide 3D cell guidance to mimic complex tissue matrices. Biomaterials 163:128-141 (2018). PubMed: 29459322
  • Ferreira SA  et al. Neighboring cells override 3D hydrogel matrix cues to drive human MSC quiescence. Biomaterials 176:13-23 (2018). PubMed: 29852376
  • Ferreira SA  et al. Bi-directional cell-pericellular matrix interactions direct stem cell fate. Nat Commun 9:4049 (2018). PubMed: 30282987
  • Tran LNK  et al. The Combination of Metformin and Valproic Acid Induces Synergistic Apoptosis in the Presence of p53 and Androgen Signaling in Prostate Cancer. Mol Cancer Ther 16:2689-2700 (2017). PubMed: 28802253
  • Yang Y  et al. Skp2 is associated with paclitaxel resistance in prostate cancer cells. Oncol Rep 36:559-66 (2016). PubMed: 27175797
  • Dong P  et al. Induction of paclitaxel resistance by ERa mediated prohibitin mitochondrial-nuclear shuttling. PLoS One 8:e83519 (2013). PubMed: 24376711
  • Lai SL  et al. In vitro and in vivo anti-angiogenic activities of Panduratin A. PLoS One 7:e38103 (2012). PubMed: 22666456
  • Materazzi S  et al. TRPA1 and TRPV4 mediate paclitaxel-induced peripheral neuropathy in mice via a glutathione-sensitive mechanism. Pflugers Arch 463:561-9 (2012). PubMed: 22258694
  • Lee ST  et al. Alpha-tomatine induces apoptosis and inhibits nuclear factor-kappa B activation on human prostatic adenocarcinoma PC-3 cells. PLoS One 6:e18915 (2011). PubMed: 21541327

Customer reviews and Q&As

Show All Reviews Q&A
Submit a review Submit a question

Isolation of microtubules using paclitaxel

Excellent
Abreviews
Abreviews
abreview image
Microtubules (MT) were isolated from SH-SY5y cells using protocol outlined in: Sloboda RD. 2014b. Isolation of microtubules and microtubule-associated proteins using paclitaxel. Cold Spring Harb Protoc doi: 10.1101/pdb .prot081190.
Following isolation, 20 μg of protein from the MT extract was immunoblotted for detecting B-3-Tubulin (Primary antibody - 1:500 dilution overnight, Secondary antibody (ab6728) - 1: 2000 dilution for 1h).
The reviewer received a reward from Abcam’s Loyalty Program in thanks for submitting this Abreview and for helping the scientific community make better-informed decisions.

Abcam user community

Verified customer

Submitted Feb 28 2018

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Get resources and offers direct to your inbox Sign up
A-Z by research area
  • Cancer
  • Cardiovascular
  • Cell biology
  • Developmental biology
  • Epigenetics & Nuclear signaling
  • Immunology
  • Metabolism
  • Microbiology
  • Neuroscience
  • Signal transduction
  • Stem cells
A-Z by product type
  • Primary antibodies
  • Secondary antibodies
  • Biochemicals
  • Isotype controls
  • Flow cytometry multi-color selector
  • Kits
  • Loading controls
  • Lysates
  • Peptides
  • Proteins
  • Slides
  • Tags and cell markers
  • Tools & Reagents
Help & support
  • Support
  • Make an Inquiry
  • Protocols & troubleshooting
  • Placing an order
  • RabMAb products
  • Biochemical product FAQs
  • Training
  • Browse by Target
Company
  • Corporate site
  • Investor relations
  • Company news
  • Careers
  • About us
  • Blog
Events
  • Tradeshows
  • Conferences
International websites
  • abcam.cn
  • abcam.co.jp

Join with us

  • LinkedIn
  • facebook
  • Twitter
  • YouTube
  • Terms of sale
  • Website terms of use
  • Cookie policy
  • Privacy policy
  • Legal
  • Modern slavery statement
© 1998-2023 Abcam plc. All rights reserved.