Paclitaxel, Anticancer agent (ab120143)
- Datasheet
- References (5)
Overview
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Product namePaclitaxel, Anticancer agent
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DescriptionAnticancer agent
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Alternative names
- Taxol
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Biological description
Anticancer agent. Inhibits depolymerization of microtubules, causing mitotic arrest in cancer cells, and apoptosis.
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Purity> 98%
Properties
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Chemical name5β,20-Epoxy-1,2α,4,7β,10β,13α-hexahydroxytax-11-en-9-one 4,10-diacetate 2-benzoate 13-ester with (2R,3S)-N-benzoyl-3-phenylisoserine
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Molecular weight853.91
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Chemical structure
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Molecular formulaC47H51NO14
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CAS Number33069-62-4
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PubChem identifier36314
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Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
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Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 25 mM
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Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Note: Some researchers have found solubility issues in PBS. The recommended procedure (from researcher feedback) for successful solubilisation is as follows: Solubilise 10 mg of ab120143 in 1.25 mL ethanol absolute, mix well, add 1.25mL Cremophor, homogenise. Store at -20°C and after 24 h, defreeze quickly and solubilise in PBS, no crystallisation observed. Please note, Abcam has not yet tested this method.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILESO=C(N[C@@H](c1ccccc1)[C@@H](O)C(=O)O[C@H]5C[C@@]6(O)[C@@H](OC(=O)c2ccccc2)[C@H]3[C@@](C)([C@@H](O)C[C@H]4OC[C@@]34OC(C)=O)C(=O)[C@H](OC(C)=O)C(=C5C)C6(C)C)c7ccccc7
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Source
Synthetic
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Research areas
References
This product has been referenced in:
- Miller ML & Ojima I Chemistry and chemical biology of taxane anticancer agents. Chem Rec 1:195-211 (2001). Read more (PubMed: 11895119) »
- Wang TH et al. Paclitaxel-induced cell death: where the cell cycle and apoptosis come together. Cancer 88:2619-28 (2000). Read more (PubMed: 10861441) »
- Kuhn JG Pharmacology and pharmacokinetics of paclitaxel. Ann Pharmacother 28:S15-7 (1994). Read more (PubMed: 7915153) »
